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SLC22A18 Antibody

  • 货号：
    CSB-PA011444
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from COLO205 cells, using ORCTL-2 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC22A18 Polyclonal antibody
  • Uniprot No.：
    Q96BI1
  • 基因名：
    SLC22A18
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from C-terminal of Human ORCTL-2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.
  • 基因功能参考文献：
    1. Data provide evidence that SLC22A18 and/or CDKN1C are tumor modifier genes involved in the tumorigenesis of SDHD-mutated paraganglioma. PMID: 27402879
    2. Establish SLC22A18 as a tumor suppressor in colon epithelial cells and propose that SLC22A18 is potentially a marker of diagnostic and prognostic values. PMID: 26196590
    3. microRNA-137 functions as a tumor suppressor in human non-small cell lung cancer by targeting SLC22A18 PMID: 25498886
    4. Upregulated expression of SLC22A18 enhanced the radiosensitivity of glioma U251 cells. PMID: 24481489
    5. SLC22A18 protein expression predicted a significantly shorter overall survival in 51 patients receiving TMZ therapy, whereas no differences in overall survival were observed in 35 patients without TMZ therapy PMID: 23514245
    6. SLC22A18 functions as a tumor suppressor in glioma and represents a candidate biomarker for long-term survival in this disease. PMID: 22153794
    7. The expression level of SLC22A18 in non-small cell lung cancer was significantly higher than that in normal tissue. PMID: 22237119
    8. SLC22A18 downregulation via promoter methylation is associated with the development and progression of glioma. PMID: 21936894
    9. Low expression of SLC22A18 was associated with tumor progression, recurrence and poor survival after breast surgery PMID: 21144813
    10. SLC22A18 gene is imprinted, with preferential expression from the maternal allele. PMID: 9751628
    11. involved in the drug resistance mechanism of tumors PMID: 11925925
    12. UbcH6-RING105 may define a novel ubiquitin-proteasome pathway that targets TSSC5 in mammalian cells PMID: 16314844
    13. study reports the imprinting status of SLC22A18AS in breast tissue and breast cancer, and shows that gain of imprinting affects both the sense, and antisense transcripts at this locus PMID: 16624517
    14. Mutational analysis of the two Sp1 sites suggested their requirement for the promoter activityof SLC22A18. PMID: 18996451
    15. recent demonstration that the promoter of this gene is positively regulated by Sp1 PMID: 18996451

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  • 相关疾病：
    Lung cancer (LNCR); Rhabdomyosarcoma, embryonal, 1 (RMSE1)
  • 亚细胞定位：
    Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
  • 组织特异性：
    Expressed at high levels in adult and fetal kidney and liver, and adult colon. Expressed in fetal renal proximal tubules (at protein level). Expressed at lower levels in heart, brain and lung.
  • 数据库链接：

    HGNC: 10964

    OMIM: 114480

    KEGG: hsa:5002

    STRING: 9606.ENSP00000307859

    UniGene: Hs.50868