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SLC24A4 Antibody

  • 货号：
    CSB-PA939107
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA939107(SLC24A4 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q8NFF2
  • 基因名：
    SLC24A4
  • 别名：
    Na(+)/K(+)/Ca(2+)-exchange protein 4 antibody; NCKX4 antibody; NCKX4_HUMAN antibody; SHEP6 antibody; SLC24A2 antibody; SLC24A4 antibody; Sodium/potassium/calcium exchanger 4 antibody; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 4 antibody; Solute carrier family 24 member 4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human SLC24A4
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis.
  • 基因功能参考文献：
    1. no significant relation was noted between SLC24A4 rs10498633 and late-onset Alzheimer;s disease risk in neither apolipoprotein E (APOE) epsilon4 carriers nor non-carriers after adjusting for age and gender PMID: 27215332
    2. pigment cells express robust, functional NCKX4 activity PMID: 27093457
    3. mutations in SLC24A4 and SLC24A5 are responsible for the phenotypic defects observed in human amylogenesis imperfecta and non-syndromic oculocutaneous albinism patients. PMID: 27129268
    4. The expressions of NCX1 and NCKX4 were significantly higher in the patent ductus arteriosus group at both the protein and mRNA levels. PMID: 25500693
    5. enamel maturation is dependent upon STIM1 and SLC24A4 function, and that there are important differences in the Ca(2+) transcellular transport systems used by secretory- and maturation-stage ameloblasts. PMID: 24621671
    6. Brain DNA methylation in sLC24A4 was associated with pathological Alzheimer disease. PMID: 25365775
    7. These findings support a key role for SLC24A4 in calcium transport during enamel formation. PMID: 23375655
    8. Taken together, these data demonstrate a potentially important role for NCX1 in control of Ca2+ homeostasis and link store depletion via STIM1 directly with NCX activation. PMID: 21126331
    9. identification and sequencing, as well as mapping to chromosomal region 14q32 PMID: 12379639
    10. IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation. PMID: 18483556

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  • 相关疾病：
    Amelogenesis imperfecta, hypomaturation type, 2A5 (AI2A5)
  • 亚细胞定位：
    Cytoplasm. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC24A subfamily
  • 组织特异性：
    Expressed abundantly in all regions of the brain, aorta, lung and thymus. Expressed at lower levels in the stomach and intestine.
  • 数据库链接：

    HGNC: 10978

    OMIM: 210750

    KEGG: hsa:123041

    STRING: 9606.ENSP00000431840

    UniGene: Hs.385530