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SLC28A2 Antibody

  • 货号：
    CSB-PA001737
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 3T3 cells using CNT2 Polyclonal Antibody
    • Western Blot analysis of NIH-3T3 cells using CNT2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O43868
  • 基因名：
    SLC28A2
  • 别名：
    SLC28A2 antibody; CNT2 antibody; Sodium/nucleoside cotransporter 2 antibody; Concentrative nucleoside transporter 2 antibody; CNT 2 antibody; hCNT2 antibody; Na(+)/nucleoside cotransporter 2 antibody; Sodium-coupled nucleoside transporter 2 antibody; Sodium/purine nucleoside co-transporter antibody; SPNT antibody; Solute carrier family 28 member 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CNT2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.
  • 基因功能参考文献：
    1. results that validate the newly developed structural homology model of CNT membrane architecture for human CNTs, revealed extended conformationally mobile regions within transport-domain TMs, identified pore-lining residues of functional importance, and provided evidence of an emerging novel elevator-type mechanism of transporter function. PMID: 28385889
    2. association between ribavirin (RBV) serum levels and SLC28A2 rs11854484 genotype, as well as the replicated association of ITPA and SLC28A3 genetic polymorphisms with RBV-induced anemia and treatment response PMID: 23195617
    3. genetic association studies in population in Italy: Data suggest that 3 SNPs (SLC28A2 rs11854484; IL28B, rs8099917; CYP27B1, rs4646536) are associated with pharmacokinetics of ribavirin and thus, sustained virologic response in hepatitis C patients. PMID: 23149444
    4. These findings support the theory that CNT2 plays roles other than salvage and establishes links with energy metabolism. PMID: 20506327
    5. there are notable species differences in the specificity of SPNT for synthetic nucleoside analogs. PMID: 12110519
    6. Characterization of sodium-dependent nucleoside transporter hCNT2 cloned from duodenum. PMID: 12893280
    7. Human nucleoside transporters involved in cellular uptake of Bbenzamide riboside and tiazofurin and their role in cytotoxicity. PMID: 15486050
    8. analysis of polymorphisms in the human concentrative nucleoside transporter, CNT2 PMID: 15861032
    9. Results identify the critical domains and amino acid residues that contribute to the observed difference in specificity between concentrative nucleoside transporter (CNT)2 orthologs. PMID: 16840788
    10. HNF4alpha is a major determinant of SLC28A1 expression, whereas C/EBPalpha and HNF3gamma modulate SLC28A2 gene expression. PMID: 17187757
    11. hCNT2 shares common cation specificity and coupling characteristics with hCNT1, which differ markedly from those of hCNT3. PMID: 17453413
    12. This study shows that adenosine elimination on human airway epithelia is mediated by ADA1, CNT2, and CNT3, which constitute important regulators of adenosine-mediated inflammation. PMID: 17696452
    13. Five novel nonsynonymous variants (L12R, R142H, E172D, E385K, M612T) expressed in U-251 cells revealed that all except E385K can uptake various substrates of CNT2: inosine, ribavirin and uridine. PMID: 17700367
    14. These data suggest that selected genes of the SLC28 and SLC29 families are not only targets of HIV-1 infection, but might also contribute to the development of adipose tissue alterations leading to lipodystrophy. PMID: 17926640
    15. Report expression and hepatobiliary transport characteristics of CNT2 in sandwich-cultured human hepatocytes. PMID: 18635603
    16. Single nucleotide polymorphisms of this protein may play a role in variation in the pharmacokinetics and pharmacological effects of nucleoside analogs. PMID: 19098160
    17. Clinical trial of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20028759

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Concentrative nucleoside transporter (CNT) (TC 2.A.41) family
  • 组织特异性：
    Expressed in heart and skeletal muscle followed by liver, kidney, intestine, pancreas, placenta and brain. Weak expression in lung.
  • 数据库链接：

    HGNC: 11002

    OMIM: 606208

    KEGG: hsa:9153

    STRING: 9606.ENSP00000315006

    UniGene: Hs.367833