Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. SLC2A12 Antibody

SLC2A12 Antibody

  • 货号：
    CSB-PA067005
  • 规格：
    ￥1100
  • 图片：
    • The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA067005 at dilution 1/30. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q8TD20
  • 基因名：
    SLC2A12
  • 别名：
    Glucose transporter type 12 antibody; GLUT 12 antibody; GLUT-12 antibody; GLUT12 antibody; GLUT8 antibody; GTR12_HUMAN antibody; SLC2A12 antibody; Solute carrier family 2 (facilitated glucose transporter) member 12 antibody; Solute carrier family 2 facilitated glucose transporter member 12 antibody; Solute carrier family 2 member 12 antibody; Solute carrier family 2, facilitated glucose transporter member 12 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human SLC2A12
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Insulin-independent facilitative glucose transporter.
  • 基因功能参考文献：
    1. GLUT12-knockdown completely abrogated high glucose-induced migration, indicating that GLUT12 functionally participates in sensing high glucose concentrations. PMID: 29187448
    2. GLUT12 is a versatile transporter: it transports a wide diversity of hexoses, it can work as a Na+ or H+/glucose symporter, and it shows electrogenic properties. PMID: 25855082
    3. findings show the level of expression of GLUT12 was significantly higher in Alzheimer's disease compare to aged controls PMID: 24820014
    4. Intestinal dehydroascorbic acid (DHA) transport is mediated by the facilitative sugar transporters, GLUT2 and GLUT8 PMID: 23396969
    5. Embedded in microvillous (maternal-facing) and basal (fetal-facing) membranes of syncytiotrophoblast, main placental barrier layer. (review) PMID: 12583599
    6. Glucose transport properties and hexose affinities of GLUT12. PMID: 12914765
    7. GLUT12 protein was localized to the apical membrane of human and rat distal tubules and collecting ducts. Levels of both GLUT1 and GLUT12 are elevated in animal models of hypertension and diabetic nephropathy. PMID: 16091581
    8. GLUT4 and GLUT12 were predominantly expressed in type I oxidative fibers; however, GLUT5 was expressed predominantly in type II (white) fibers PMID: 16803853
    9. Translocation of GLUT12 in cultured myoblasts was dependent on activation of PI3-K. PMID: 19549745

    显示更多

    收起更多

  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region.
  • 蛋白家族：
    Major facilitator superfamily, Sugar transporter (TC 2.A.1.1) family, Glucose transporter subfamily
  • 组织特异性：
    Predominantly expressed in skeletal muscle, heart and prostate, with lower levels in brain, placenta and kidney.
  • 数据库链接：

    HGNC: 18067

    OMIM: 610372

    KEGG: hsa:154091

    STRING: 9606.ENSP00000275230

    UniGene: Hs.486508