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SLC31A2 Antibody

  • 货号：
    CSB-PA021577LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA021577LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA021577LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA021577LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC31A2 Polyclonal antibody
  • Uniprot No.：
    O15432
  • 基因名：
    SLC31A2
  • 别名：
    SLC31A2; COPT2; CTR2; Probable low affinity copper uptake protein 2; Copper transporter 2; hCTR2; Solute carrier family 31 member 2
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Probable low affinity copper uptake protein 2 protein (44-93AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLC31A2 Antibody (CSB-PA021577LA01HU)，的标记方式是Non-conjugated。对于SLC31A2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA021577LB01HU SLC31A2 Antibody, HRP conjugated ELISA
    FITC CSB-PA021577LC01HU SLC31A2 Antibody, FITC conjugated
    Biotin CSB-PA021577LD01HU SLC31A2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in low-affinity copper uptake.
  • 基因功能参考文献：
    1. 11 single-nucleotide polymorphisms (SNPs) in CTR1, CTR2, ATP7A, and ATP7B were genotyped in these patients. PMID: 28737129
    2. Decreased expression of CTR2 is associated with clear cell renal cell carcinoma. PMID: 26411550
    3. Over-expression of CTR2 increased exchangeable Cu(+) by 150% and rendered the human epithelial 2008 cancer cell model 2.5-fold resistant to cisplatin. PMID: 24522273
    4. Increased CTR2 expression is associated with platinum resistance in epithelial ovarian cancer. PMID: 23564780
    5. hCTR2 is as an oligomeric membrane protein localized in lysosomes, which stimulates copper delivery to the cytosol of human cells at relatively high copper concentrations. PMID: 17617060
    6. Ctr2 promotes copper uptake at the plasma membrane and plays a role in regulating copper levels in COS-7 cells PMID: 17944601
    7. CTR2 functions by limiting drug accumulation, and its expression correlates with the sensitivity of human ovarian carcinoma cell lines to cisplatin. PMID: 19509135

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Copper transporter (Ctr) (TC 1.A.56) family, SLC31A subfamily
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 11017

    OMIM: 603088

    KEGG: hsa:1318

    STRING: 9606.ENSP00000259392

    UniGene: Hs.24030