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SLC33A1 Antibody

  • 货号：
    CSB-PA13339A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA13339A0Rb at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA13339A0Rb at dilution of 1:100
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, HepG2 whole cell lysate, Mouse liver tissue, Mouse kidney tissue, Mouse brain tissue
      All lanes: SLC33A1 antibody at 2.5μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 61 kDa
      Observed band size: 50 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC33A1 Polyclonal antibody
  • Uniprot No.：
    O00400
  • 基因名：
    SLC33A1
  • 别名：
    ACATN antibody; ACATN_HUMAN antibody; Acetyl CoA transporter antibody; Acetyl Coenzyme A transporter antibody; Acetyl coenzyme A transporter 1 antibody; Acetyl-CoA transporter 1 antibody; Acetyl-coenzyme A transporter 1 antibody; AT 1 antibody; AT-1 antibody; AT1 antibody; Human Angiotensin II Type 1 Receptor antibody; Slc33a1 antibody; Solute carrier family 33 (acetyl CoA transporter) member 1 antibody; Solute carrier family 33 member 1 antibody; spastic paraplegia 42 (autosomal dominant) antibody; SPG42 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Acetyl-coenzyme A transporter 1 protein (1-74AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLC33A1 Antibody (CSB-PA13339A0Rb)，的标记方式是Non-conjugated。对于SLC33A1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA13339B0Rb SLC33A1 Antibody, HRP conjugated ELISA
    FITC CSB-PA13339C0Rb SLC33A1 Antibody, FITC conjugated
    Biotin CSB-PA13339D0Rb SLC33A1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides. Negatively regulates BMP signaling.
  • 基因功能参考文献：
    1. results indicate that increased expression of AT-1 can cause an autistic-like phenotype by affecting key neuronal metabolic pathways. PMID: 27242167
    2. SLC33A1 can negatively regulate BMP signaling. PMID: 25402622
    3. Homozygosity mapping displayed a region of commonality among three families at chromosome 3q25. Deep sequencing and conventional sequencing disclosed homozygous or compound heterozygous mutations for all affected subjects in SLC33A1. PMID: 22243965
    4. translocates acetyl-CoA into the ER lumen and is essential for cell viability PMID: 20826464
    5. A missense mutation in SLC33A1 causes autosomal-dominant spastic paraplegia. PMID: 19061983

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  • 相关疾病：
    Spastic paraplegia 42, autosomal dominant (SPG42); Congenital cataracts, hearing loss, and neurodegeneration (CCHLND)
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    SLC33A transporter family
  • 组织特异性：
    Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. With strongest signals in pancreas.
  • 数据库链接：

    HGNC: 95

    OMIM: 603690

    KEGG: hsa:9197

    STRING: 9606.ENSP00000352456

    UniGene: Hs.478031