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SLC38A2 Antibody

  • 货号：
    CSB-PA030122
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q96QD8
  • 基因名：
  • 别名：
    Amino acid transporter 2 antibody; Amino acid transporter A2 antibody; ATA2 antibody; KIAA1382 antibody; PRO1068 antibody; Protein 40-9-1 antibody; S38A2_HUMAN antibody; SAT2 antibody; Slc38a2 antibody; SNAT2 antibody; Sodium-coupled neutral amino acid transporter 2 antibody; Solute carrier family 38 member 2 antibody; System A amino acid transporter antibody; System A amino acid transporter 2 antibody; System A transporter 1 antibody; System N amino acid transporter 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human SNAT2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.
  • 基因功能参考文献：
    1. there is a disulfide bond between Cys245 and Cys279 in SNAT2 which has no effect on cell surface trafficking, as well as transporter function PMID: 27355203
    2. In the absence of SLC1A5 there is a crucial role of SNAT1 in supplying glutamine for glutaminolysis with SNAT2 acting as a "backup" for glutamine transport. PMID: 27129276
    3. Propose regulation of placental SNAT2/LAT1 ubiquitination by mTORC1 and Nedd4-2. PMID: 26608079
    4. Decreased placental mTOR activity causes down-regulation of placental system A activity by shifting SNAT-2 trafficking towards proteasomal degradation, thereby contributing to decreased fetal amino acid availability and restricted fetal growth in IUGR. PMID: 26374858
    5. GADD34 promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter SNAT2. PMID: 26041779
    6. Increased availability of unsaturated fatty acids can compromise the stress-induced induction/adaptation in SNAT2 expression. PMID: 25653282
    7. SLC38A1 and SLC38A2 transcript levels are altered in placental malaria with intervillositis. PMID: 23408887
    8. SNAT2 mRNA levels were significantly decreased in intrauterine growth-restricted placentas with reduced umbilical blood flows. PMID: 23728383
    9. Placental mRNA expression of system A transporter isoforms SLC38A1 and -2 was lower in teenagers than in adults which may underlie their susceptibility to delivering small-for-gestational-age infants. PMID: 22028413
    10. findings show methylation status of rRNA differentially influenced the mechanism of 80S complex formation on IRES elements from SNAT2)versus the hepatitis C virus mRNA PMID: 21930789
    11. Proteomic analysis of TAP-tag purified SNAT2 fusion proteins identified two novel SNAT2-interacting proteins that may potentially function in conjunction with SNAT2 transceptor to regulate signalling pathways influencing protein turnover and cell growth PMID: 21622135
    12. Lower placental system A activity in women who reported strenuous exercise and had a lower arm muscle area may reflect an adaptation in placental function which protects maternal resources in those with lower nutrient reserves. PMID: 20206993
    13. SNAT2 amino acid response element, along with a nearby conserved CAAT box, has enhancer activity and it confers regulated transcription to a heterologous promoter PMID: 14623874
    14. The synthesis of SNAT2 is required for the hypertonic stimulation of system A transport activity. PMID: 15581851
    15. Up-regulation of SNAT2 is essential for the rapid restoration of cell volume after hypertonic stress. PMID: 15922329
    16. Amino acid depletion was associated with an up-regulation of amino acid transport system A activity, largely mediated through an enhancement of SNAT2 expression at both the protein and mRNA level in BeWo cells. PMID: 16125834
    17. deficient in the amino acid response pathway exhibited little or no induction of SNAT2 mRNA PMID: 16445384
    18. The strong expression of Na(+)-coupled neutral amino acid transporter 2 in the somato-dendritic compartment and in non-neuronal elements that are integral parts of the blood-brain and brain-cerebrospinal fluid barrier. PMID: 16616430
    19. SNAT2 expression can be modulated by specific signaling pathways in response to different stresses PMID: 16621798
    20. Results suggest that cortisol may be involved in upregulation of system A (SNAT2)in the placenta to ensure sufficient amino acid supply to the developing fetus. PMID: 16621896
    21. Therefore, we can speculate that such anion-conducting pathways are general features of Na+-transporting systems. PMID: 17237199
    22. Despite increased ATF4 binding at the C/EBP-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed PMID: 18697751
    23. Report SNAT2 activity in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. PMID: 18703994
    24. analysis of a conserved Na(+) binding site of the sodium-coupled neutral amino acid transporter 2 PMID: 19589777
    25. we have identified a novel regulatory pathway involving increased gene expression of the SNAT2 isoform mediated by a STAT-dependent pathway, which links IL-6 to increased activity of amino acid transporter system A PMID: 19741197

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Amino acid/polyamine transporter 2 family
  • 组织特异性：
    Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein
  • 数据库链接：

    HGNC: 13448

    OMIM: 605180

    KEGG: hsa:54407

    STRING: 9606.ENSP00000256689

    UniGene: Hs.221847