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SLC4A2 Antibody

  • 货号：
    CSB-PA021667DSR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA021667DSR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA021667DSR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC4A2 Polyclonal antibody
  • Uniprot No.：
    P04920
  • 基因名：
    SLC4A2
  • 别名：
    AE 2 antibody; AE2 anion exchanger antibody; Anion exchange protein 2 antibody; Anion exchanger 2 antibody; B3A2_HUMAN antibody; BAND 3-LIKE PROTEIN antibody; BND3L antibody; EPB3L1 antibody; erythrocyte band 3 antibody; Erythrocyte membrane protein band 3 like 1 antibody; HKB3 antibody; MPB3L antibody; NBND3 antibody; Non-erythroid band 3-like protein antibody; Slc4a2 antibody; Solute carrier family 4 member 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Anion exchange protein 2 protein (95-245AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plasma membrane anion exchange protein of wide distribution.
  • 基因功能参考文献：
    1. The regulation of a basolateral located, DIDS-sensitive, Cl(-)/HCO3(-) exchanger, anion exchanger 2 (AE2; SLC4A2) which is postulated to act as an acid loader, and therefore potential regulator of HCO3(-) secretion, in human airway epithelial cells. PMID: 28455748
    2. To match the stimulatory effect on acid uptake, cell-to-cell coupling in NHDF-Ad and CCD-112-CoN cells was strengthened with TGFbeta1.Importantly, the activities of stromal AE2 and connexin-43 do not place an energetic burden on cancer cells, allowing resources to be diverted for other activities PMID: 27543333
    3. ABA transport in human nucleated cells occurs via the anion exchanger AE2 PMID: 27015766
    4. down-regulation in primary biliary cholangitis sensitizes cholangiocytes to apoptotic insults by activating soluble adenylyl cyclase PMID: 26991014
    5. regulatory proteins for Cl(-)/HCO3(-) exchanger 2 activity PMID: 26716707
    6. AE2 is a major pathway for basolateral Cl(-) loading during cAMP-stimulated secretion of Cl(-) and fluid by Calu-3 cells PMID: 22802585
    7. A novel signal pathway involved in gastrin-stimulated AE2 expression mediated by EGR1 in gastric cancer cells. PMID: 23121767
    8. miR-506 is up-regulated in primary biliary cirrhosis, binds the 3'UTR region of AE2 mRNA, and prevents protein translation, leading to diminished AE2 activity and impaired biliary secretory functions. PMID: 22383162
    9. CTLA4 and SLC4A2 genetic polymorphisms are differentially associated with primary biliary cirrhosis development and progression, as well as anti-gp210 or anti-centromere antibody production, in Japanese PBC patients PMID: 21594562
    10. Dysfunctions related to AE2 might have a role in the pathogenesis of primary biliary cirrhosis. PMID: 21691115
    11. AE2 mediated-apoptosis of endothelial cells induced by high glucose was Caspase-3-dependent. PMID: 20180022
    12. AE2 operates in parallel with NHE1 to regulate pH(i) during RVD of human cervical cancer cells. PMID: 11852051
    13. Oxidative stress activates anion exchange protein 2 and AP-1 in airway epithelial cells. PMID: 12225956
    14. findings suggest that HNF1 may have a major role in upregulating alternative transcription of the AE2 gene in the liver, and therefore it may contribute to the biliary secretion of bicarbonate in response to certain stimuli PMID: 14575719
    15. The results indicated that overexpression of AE2 may be involved in the development of human HCC. PMID: 17058451
    16. SLC4A2 colocalized with carbonic anhydrase IX in gastric mucosa. PMID: 17652430
    17. AE2 might be associated with gastric carcinogenesis and the achlorhydria experienced by gastric cancer patients. PMID: 18438347
    18. that AE2 may play an important role in the progression of hepatocellular carcinoma cells PMID: 19224338
    19. The common genetic variation of SLC4A2 does not directly affect the risk of PBC or its clinical outcome. PMID: 19491853

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Anion exchanger (TC 2.A.31) family
  • 数据库链接：

    HGNC: 11028

    OMIM: 109280

    KEGG: hsa:6522

    STRING: 9606.ENSP00000405600

    UniGene: Hs.647069