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SLC52A3 Antibody

  • 货号：
    CSB-PA873618LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse lung tissue
      All lanes: Q9NQ4 antibody at 3.2μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 51, 46 kDa
      Observed band size: 51 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA873618LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA873618LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: MCF-7 whole cell lysate
      All lanes: SLC52A3 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 51, 46 kDa
      Observed band size: 51 kDa
  • 其他：

产品详情

  • 产品描述：

    The SLC52A3 polyclonal antibody is generated by immunizing a rabbit with a synthetic peptide corresponding to the 159-220 amino acids of the recombinant human SLC52A3 protein. The resulting polyclonal antibody mixture is then purified through protein G affinity chromatography. Its purity exceeds 95%. The purified SLC52A3 antibody is tested for specificity and affinity in ELISA, WB, IHC, and IF applications to ensure its ability to bind to the SLC52A3 protein. It can react with human and mouse samples.

    The target protein SLC52A3 mainly functions to facilitate the uptake of riboflavin from the extracellular environment into cells by acting as a high-affinity riboflavin transporter. This process is crucial for maintaining adequate levels of riboflavin in cells and tissues. SLC52A3 has also been implicated in the regulation of cell growth and proliferation in cancer cells.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC52A3 Polyclonal antibody
  • Uniprot No.：
    Q9NQ40
  • 基因名：
    SLC52A3
  • 别名：
    bA371L19.1 antibody; BVVLS antibody; BVVLS1 antibody; C20orf54 antibody; C20orf54provided by HGNC antibody; Chromosome 20 open reading frame 54 antibody; hRFT2 antibody; member 3 antibody; MGC10698 antibody; RFT2 antibody; RFVT3 antibody; Riboflavin transporter 2 antibody; riboflavin transporter antibody; riboflavin transporter, member 3 antibody; S52A3_HUMAN antibody; Slc52a3 antibody; solute carrier family 52 (riboflavin transporter), member 3 antibody; Solute carrier family 52 antibody; solute carrier family 52, riboflavin transporter, member 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Solute carrier family 52, riboflavin transporter, member 3 protein (159-220AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLC52A3 Antibody (CSB-PA873618LA01HU)，的标记方式是Non-conjugated。对于SLC52A3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA873618LB01HU SLC52A3 Antibody, HRP conjugated ELISA
    FITC CSB-PA873618LC01HU SLC52A3 Antibody, FITC conjugated
    Biotin CSB-PA873618LD01HU SLC52A3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption.
  • 基因功能参考文献：
    1. The riboflavin transporter-3 (SLC52A3) 5'-flanking regions contain NF-kappaB p65/Rel-B-binding sites, which are crucial for mediating SLC52A3 transcriptional activity in esophageal squamous cell carcinoma (ESCC) cells. PMID: 29428966
    2. RFVT3 gene and protein expression levels were higher in DLD-1 and HT-29 compared to Caco2 cells. In tumor tissues of patients with CRC, RFVT3 gene expression levels were increased, while protein expression was reduced, with a small reduction in riboflavin amount. PMID: 29715086
    3. our knowledge, this is the first report to indicate that Rfvt3 contributes to placental riboflavin transport, and that disruption of Slc52a3 gene caused neonatal mortality with hyperlipidemia and hypoglycemia owing to riboflavin deficiency. PMID: 27272163
    4. This study found that RFT2 was overexpressed in glioma samples compared with normal brain tissue. PMID: 27584688
    5. RFVT3 is a target for posttranscriptional regulation by miR-423-5p in intestinal epithelial cells, and this regulation has functional consequences on intestinal riboflavin (RF) uptake process. PMID: 28912250
    6. Fourteen mutations in SLC52a3 were associated with Brown-Vialetto-Van Laere syndrome. PMID: 29053833
    7. SLC52A3 rs13042395 C>T polymorphism was associated with decreased cancer risk in the normal body mass index group, whereas no association was present in obesity group. PMID: 27600099
    8. Single nucleotide polymorphism rs13042395 in the SLC52A3 TT genotype carriers were likely to have reduced lymph node metastasis and longer relapse-free survival time. PMID: 27472962
    9. This study also identified a number of residues in the hRFVT-3 polypeptide that are important for its function/cell surface expression. PMID: 28637675
    10. RFT2 plays an important role in gastric carcinogenesis by modulating riboflavin absorption PMID: 26722538
    11. C20orf54 rs13042395 polymorphism was significantly associated with decreased ESCC and GCA risk especially for the subjects with under-weight or normal. PMID: 26154995
    12. A close association exists between functional SNP rs3746804 in C20orf54 and susceptibility to esophageal squamous cell carcinoma PMID: 25427582
    13. the single-nucleotide polymorphism rs13042395 in C20orf54 showed a significantly lower risk of esophageal squamous cell carcinoma in the younger age group but no significant association in the older group in a Korean population. PMID: 24152165
    14. Binding of Sp1 to the minimal SLC52A3 promoter. PMID: 25394472
    15. Increase in methylation of CpG 2 and CpG 3 in hRFT2gene promoter region is associated with the genesis of cervical squamous cell carcinoma. PMID: 24761851
    16. Results suggest that RFT2 contributes to esophageal squamous cell carcinoma tumorigenesis and may serve as a potential therapeutic target. PMID: 25045844
    17. C20orf54 expression were significantly up-regulated in CSCC. PMID: 24260322
    18. These results strongly suggest that RFVT3 would functionally be involved in riboflavin absorption in the apical membranes of intestinal epithelial cells PMID: 24264046
    19. Defective expression of C20orf54 is associated with the development of Kazak esophageal squamous cell carcinoma and this may represent a mechanism underlying the decreased plasma riboflavin levels in ESCC. PMID: 23275236
    20. RFT2 protein functional single nucleotide polymorphism might be associated with the development of esophageal squamous cell carcinoma. PMID: 22533825
    21. Identification of novel mutations that affect amino acid changes in Brown-Vialetto-Van Laere syndrome patients. PMID: 22718020
    22. Defective expression of RFT2 is associated with the development of gastric carcinoma and may result in decreased plasma riboflavin levels in GC. PMID: 22791947
    23. Single nucleotide polymorphism in C20orf54 gene is associated with esophageal squamous cell carcinoma. PMID: 22471455
    24. Mutations of riboflavin transporter-2 gene is associated with Brown-Vialetto-Van Laere syndrome. PMID: 22273710
    25. These results demonstrate a potential role for specific cysteine residues in the cell surface expression of riboflavin transporter 2 in human intestinal epithelial cells. PMID: 21512156
    26. results indicate that riboflavin transporter 2(RFT2) is a transporter involved in the epithelial uptake of riboflavin in the small intestine for its nutritional utilization PMID: 20724488
    27. Susceptibility loci at C20orf54 for esophageal squamous cell carcinoma. PMID: 20729853
    28. Discusses cloning of rat riboflavin transporter 2 and identification of a comparable protein in human. PMID: 19122205
    29. identified a candidate gene, C20orf54, in a consanguineous family with Brown-Vialetto-Van Laere syndrome with multiple affected individuals and subsequently demonstrated that mutations in this gene were the cause of disease in other, unrelated families PMID: 20206331

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  • 相关疾病：
    Brown-Vialetto-Van Laere syndrome 1 (BVVLS1); Fazio-Londe disease (FALOND)
  • 亚细胞定位：
    Apical cell membrane; Multi-pass membrane protein. Cell membrane.; [Isoform 1]: Cell membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Cytoplasm.; [Isoform 2]: Cytoplasm.
  • 蛋白家族：
    Riboflavin transporter family
  • 组织特异性：
    Predominantly expressed in testis. Highly expressed in small intestine and prostate.
  • 数据库链接：

    HGNC: 16187

    OMIM: 211500

    KEGG: hsa:113278

    STRING: 9606.ENSP00000217254

    UniGene: Hs.283865