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SLC6A12 Antibody

  • 货号：
    CSB-PA021690ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: SLC6A12 antibody at 4.47µg/ml + PC-3 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 70 kDa
      Observed band size: 70 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA021690ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC6A12 Polyclonal antibody
  • Uniprot No.：
    P48065
  • 基因名：
    SLC6A12
  • 别名：
    Betaine/GABA transporter 1 antibody; BGT-1 antibody; BGT1 antibody; Gamma aminobutyric acid transporter antibody; GAT2 antibody; Na(+)/Cl(-) betaine/GABA transporter antibody; S6A12_HUMAN antibody; Slc6a12 antibody; Sodium- and chloride-dependent betaine transporter antibody; Solute carrier family 6 (neurotransmitter transporter), member 12 antibody; Solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 antibody; Solute carrier family 6 member 12 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Sodium- and chloride-dependent betaine transporter protein (515-614AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.
  • 基因功能参考文献：
    1. The SLC6A12 expression levels in peripheral blood mononuclear cells were significantly higher in TLE patients. PMID: 26690518
    2. T40 may be important for the trafficking and insertion of BGT1 in the plasma membrane PMID: 24829506
    3. JAK2 is a novel regulator of the GABA transporter BGT1. PMID: 22405821
    4. This study found that rs216250 of SLC6A12 was correlated with the Scale for the Assessment of Negative Symptoms (SANS) scores. PMID: 21367462
    5. Results showed that two polymorphisms and a haplotype in SLC6A12, were significantly associated with AIA after multiple testing corrections. PMID: 20597903
    6. The primary structure of BGT-1 predicts two putative phosphorylation sites for the Ca2+/diacylglycerol-dependent protein kinase (PKC), which regulates BGT-1 function by phosphorylation events in a transport system expressed in cultured astrocytoma cells. PMID: 12111824
    7. BGT-1 is expressed from mRNA and transports GABA in platelets. PMID: 16198020

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A12 subfamily
  • 组织特异性：
    Liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain.
  • 数据库链接：

    HGNC: 11045

    OMIM: 603080

    KEGG: hsa:6539

    STRING: 9606.ENSP00000352702

    UniGene: Hs.437174