SLC6A3 Antibody

1. genetically determined differences in DAT1 and DRD2 expression modulate functional consequences of sleep deprivation. PMID: 28393838
2. SLC6A3 gene moderates the relation between maternal history of maltreatment and infant emotion regulation. PMID: 28803562
3. The age-related reduction in striatal DAT density also predicted memory decline, suggesting that a relation between striatal functions and memory decline in aging is multifaceted. PMID: 30224467
4. genetic association studies in population of young adults in Columbia: Data suggest that genetic polymorphisms in DRD4 and SLC6A3 are associated with overweight/obesity in the population studied; DRD4 4/4 genotype is associated with lower BMI and SLC6A3 10/10 genotype is associated with higher BMI. (DRD4 = dopamine receptor D4; SLC6A3 = solute carrier family 6 member 3) PMID: 29145734
5. Cloninger's (1987) hypothesis about negative relationship between novelty seeking and dopamine was confirmed on allele level, because higher novelty seeking was found in Val allele carriers comparing to Met/Met genotype carriers. PMID: 29546858
6. Results indicate that chronic coffee consumption in Parkinson's disease (PD) patients was not associated with significant change in striatal DAT availability, even after taking into account potentially confounding factors that are probably related to dopaminergic neuron decline (age, sex, disease duration, and severity of PD), treatment, and coffee-related habit (cigarette smoking). PMID: 29362953
7. This is the first study to investigate the association of rs3910105 in SNCA [SNCA protein, human] with DAT [dopamine transporter] availability. rs3910105 had an effect on DAT availability, and the correlation between DAT availability and SNCA transcripts were significant in CT [computed tomography] genotypes of rs3910105. PMID: 29978616
8. Study describes an association between the 6R6R genotype of the intron 8 VNTR of the dopamine transporter (DAT1) gene and crack cocaine addiction. PMID: 29332099
9. None of the polymorphisms studied showed a reliable association with response inhibition performance. The methodological and theoretical implications of these findings are discussed. PMID: 29155230
10. From all the statistically significant CpGs, methylation levels of cg00997378 (SLC6A3 gene) showed the highest differences (p < 0.0001), being associated with prematurity risk factors. SLC6A3 methylation, previously related to attention-deficit/hyperactivity disorder, neuronal function and behavior, might be a potential epigenetic biomarker with value in the early diagnosis and management of neurodevelopmenta PMID: 29172706
11. Results show that Gbetagamma activation regulates DAT activity by increasing dopamine (DA) efflux, and suggests that Gbetagamma promotes an efflux-willing state of the transporter and that the activation of a GPCR can lead to a Gbetagamma-dependent DA efflux. Furthermore, the cellular responses that occur following activation of a Galphaq-coupled receptor are the result of multiple signaling pathways mediated by Galpha... PMID: 28894302
12. Findings demonstrate that histidine547 on hDAT plays a crucial role in stabilizing basal dopamine transport and Tat-DAT interaction. PMID: 27966610
13. In a study of the genetic association between polymorphisms in the DAT1, SERT, COMT and BDNF genes and attention deficit and hyperactive disorder, transmission disequilibrium test analysis showed that no individual allele of any variant studied has a preferential transmission. PMID: 29122229
14. SLC6A3 repeat allele was higher proportion in Indonesian children with ADHD than healthy controls. PMID: 29061424
15. DAT1 genotype and motor threshold interact on prepulse facilitation following brain stimulation. PMID: 28337537
16. This study demonstrate the genetic influence of a family history of alcohol use disorders and DAT and DBH gene polymorphisms on the risk of withdrawal seizures and delirium tremens. PMID: 28139629
17. Multilevel models revealed that history of care had a greater influence on maternal baseline cortisol(but not cortisol trajectory)for mothers with more plasticity alleles of SLC6A3 and OXTR, relative to mothers with fewer or no plasticity alleles. Findings indicate that a mother's history of care is related to her cortisol secretion in anticipation of infant stress, but this relation depends on her genetic characteristics PMID: 28890000
18. This combined computational-experimental study demonstrates that histidine-547 (H547) of human DAT plays a crucial role in the DAT-HIV-1 Tat binding and dopamine uptake by DAT. PMID: 27250920
19. This results of this study showed the evidence that being born SGA moderates the effect of SNPs in DAT1 (a gene previously associated with ADHD) on the risk for ADHD symptoms. PMID: 28666839
20. Findings suggest that responses to attention-grabbing features in smoking-cessation messages is affected by the DAT1 genotype. PMID: 28757070
21. The subjective responses to alcohol consumption in social drinkers were associated with significant epistatic interactions between OPRM1 and DAT1 genotypes. PMID: 28376280
22. Epigenetic alterations of DAT1 in modulating the response to methylphenidate in ADHD, primarily on oppositional and hyperactive-impulsive symptoms. PMID: 27676100
23. Studied neural activation during an emotional response inhibition task across different DAT1 genotypes in healthy individuals, showed that genotypic variation influencing basal dopamine levels can alter the neural basis of emotional processing and response inhibition. This may indicate that 9R carriers exert more effort to overcome increased basal dopamine activation when inhibiting responses in emotional contexts. PMID: 26843006
24. The current study, the effect of the dopamine transporter gene DAT1/SLC6A3 on striatal brain volume was investigated in children and adults with ADHD and healthy participants in three different cross-sectional cohorts. PMID: 26935821
25. Study analyzed effects of DRD4 and DAT1, prenatal exposure to alcohol and smoking and interactions on ADHD severity, response inhibition and neural activity. DRD4 7-repeat allele associated with less superior frontal and parietal activity & greater activity in frontal pole and occipital cortex. Alcohol-exposed had more activity in lateral orbitofrontal cortex, & DAT1 risk variant associated with lower cerebellar activity. PMID: 28234207
26. We investigated genetic associations with reflexive attention measures in infancy and childhood in the same group of children. Performance on the infant task was associated with SLC6A3. In addition, several genetic associations with an analogous child task occurred with markers on CHRNA4, COMT, and DRD4. PMID: 26613685
27. Linear regression analyses demonstrated that the increasing number of COMT158Val and DAT1 10R alleles significantly predicted increasing hyperactivity/inattention in boys at both 11 and 15 years of age. Presence of both COMT158Val and DAT1 10R alleles was also associated with full categorical attention-deficit/hyperactivity disorder diagnosis at 18 years of age in boys. Study did not observe these associations in girls. PMID: 27327562
28. Results are consistent with the suggested associations between DAT1 and risk-taking behavior. The counter-intuitive finding for partner selection and treatment adherence may be evidence of additional factors that place PLH at risk for engaging in hazardous drinking as well as relationship difficulties and problems with treatment adherence (e.g., depressive symptoms, avoidant coping, trauma history). PMID: 28278565
29. Unsubstituted amphetamine-like cathinones bind more favorably to DAT, due to a Val152 offering more space, as compared to the bulkier Ile172 in SERT. This was supported by uptake inhibition measurements, which showed an increase in activity in SERT-I172V. PMID: 27860344
30. concluded that the Variable Number Tandem Repeats polymorphism has an important role in the etiology of Alcohol Dependence, and individuals with at least 1 A9 allele are more likely to be dependent on alcohol than persons carrying the non-A9 allele. PMID: 27219321
31. Striatal DAT and diencephalic SERT binding negatively correlated with food detection speed, but not with food distraction time, ratings of hunger, craving or impulsivity. Striatal DAT and diencephalic SERT binding did not correlate with free choice food intake. PMID: 26984412
32. Participants carrying a copy of the nine-repeat DAT allele-linked to higher phasic dopamine activity-expressed amplified striatal response during anticipation of monetary gain following sleep deprivation. Moreover, participants homozygous for the ten-repeat DAT allele-linked to lower phasic dopamine activity-selectively demonstrated an increase in sensitivity to monetary loss within anterior insula following sleep loss. PMID: 26918589
33. SLC6A3 gene variants have been reported to be implicated in alcohol addiction, nicotine dependence and other addictive behaviors. PMID: 27490263
34. The 3' VNTR polymorphism affects human DAT expression level in iPSC-derived human dopaminergic neurons. PMID: 27547496
35. Study measured smooth pursuit in 110 healthy subjects genotyped for two well-documented polymorphisms, the COMT Val(158)Met polymorphism and the SLC6A3 3'-UTR-VNTR polymorphism; modulation of striatal dopamine activity by the SLC6A3 3'-UTR-VNTR polymorphism had no significant functional effect. PMID: 28101524
36. Allosteric modulation of human dopamine transporter activity under conditions promoting its dimerization PMID: 28584050
37. Maternal ADHD symptomatology, maternal DAT1, and home atmosphere contribute to boys' ADHD Symptomatology at 7 years of age. PMID: 27873141
38. A combined haplotype (9R-A2) of DAT-1 and DRD2 genes was associated with the murderer phenotype among Pakistani violent criminal inmates. PMID: 28582390
39. DAT1-10R carriers fared the same as 9R homozygotes in poorer and moderate school environments, but fared disproportionately better in more positive environments. PMID: 27786532
40. SLC6A3 gene may have a role in susceptibility to late-onset alcohol dependence in the Han Chinese population. PMID: 28182634
41. Low school engagement in adolescence is more pronounced for DAT1-10R homozygotes. PMID: 27268567
42. In children with ADHD, multiple mediation analysis revealed significant indirect associations between DAT1 genotype and inattention, hyperactivity-impulsivity, and oppositionality, with specific indirect effects through response inhibition. PMID: 27049476
43. This result suggests that persistent drug-induced parkinsonism in patients with visually normal DAT imaging may be associated with subtle decrement of DAT activity. PMID: 27294367
44. the dopamine transporter SLC6A3 constitutes a novel biomarker that is highly specific for clear cell renal cell carcinoma PMID: 27663598
45. Data suggest that variants rs28363170 and rs3836790 in the solute carrier family 6 member 3 gene are not associated with sporadic Parkinson's disease in Han Chinese population. PMID: 27353511
46. Study systematically designed and characterized a set of 24 substrate-based bivalent ligands, and in combination with mutagenesis, induced-fit docking calculations, electrophysiology, and cysteine accessibility measurements; revealed novel insight into the molecular basis of substrate recognition in hSERT and hDAT PMID: 27425420
47. these findings provide compelling experimental evidence that DAT N and C termini synergistically contribute to substrate and inhibitor affinities. PMID: 27986813
48. these results are the first demonstration of pharmacological chaperoning of DAT and suggest this may be a viable approach to increase DAT levels in Dopamine Transporter Deficiency Syndrome and other conditions associated with reduced DAT function. PMID: 27555326
49. total of 1799 differentially methylated regions were identified including SLC6A3, Rab40C, ZNF584, and FOXD3 whose significant methylation differences were confirmed in breast cancer patients through quantitative real-time polymerase chain reaction.Methylation of those aforementioned genes in white blood cells of our young patients may highlight their potential as early epimarkers PMID: 28349825
50. Data indicate genetic association between dopamine transporter SLC6A3 (DAT1) and hypertension, and the specific variable number tandem repeats (VNTR) alleles of SLC6A3 may be a risk factor for hypertension. PMID: 28055236

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HGNC: 11049

OMIM: 126455

KEGG: hsa:6531

STRING: 9606.ENSP00000270349

UniGene: Hs.406