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SLC7A2 Antibody

  • 货号：
    CSB-PA021714LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA021714LA01HU diluted at 1:400 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC7A2 Polyclonal antibody
  • Uniprot No.：
    P52569
  • 基因名：
    SLC7A2
  • 别名：
    ATRC2 antibody; 20.5 antibody; Amino acid transporter; cationic 2 (low affinity) antibody; ATRC 2 antibody; CAT 2 antibody; CAT-2 antibody; CAT2 antibody; Cat2a antibody; Cat2b antibody; Cationic amino acid transporter 2A antibody; cationic amino acid transporter; y+ system; low affinity cationic amino acid transporter 2 antibody; CTR2_HUMAN antibody; HCAT 2 antibody; HCAT2 antibody; Low affinity cationic amino acid transporter 2 antibody; OTTHUMP00000216432 antibody; OTTHUMP00000216433 antibody; OTTMUSP00000041667 antibody; OTTMUSP00000041669 antibody; RCAT2 antibody; SLC7A 2 antibody; Slc7a2 antibody; Solute carrier family 7 member 2 antibody; T cell early activation protein antibody; Tea antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cationic amino acid transporter 2 protein (604-658AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLC7A2 Antibody (CSB-PA021714LA01HU)，的标记方式是Non-conjugated。对于SLC7A2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA021714LB01HU SLC7A2 Antibody, HRP conjugated ELISA
    FITC CSB-PA021714LC01HU SLC7A2 Antibody, FITC conjugated
    Biotin CSB-PA021714LD01HU SLC7A2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). May play a role in classical or alternative activation of macrophages via its role in arginine transport.
  • 基因功能参考文献：
    1. genetic association studies in population in Tennessee: Data suggest that an SNP in SLC7A2 (rs2720574) is associated with response to dietary calcium and magnesium in prevention of colorectal polyps and colorectal ademonas. PMID: 28501704
    2. Identification of cysteine residues in human cationic amino acid transporter hCAT-2A that are targets for inhibition by N-ethylmaleimide. PMID: 24019517
    3. A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport. PMID: 22787143
    4. Addition of spermine or knockdown of CAT2 inhibited L-Arg uptake, NO production, and iNOS protein levels, whereas knockdown of ODC had the opposite effect. CAT2 and ODC were increased in mouse and human H pylori gastritis tissues. PMID: 20600019
    5. Insulin increased L-arginine transport and the mRNA levels for hCAT-1 and hCAT-2B PMID: 15064952

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Amino acid-polyamine-organocation (APC) superfamily, Cationic amino acid transporter (CAT) (TC 2.A.3.3) family
  • 组织特异性：
    Expressed at high levels in the skeletal muscle, placenta and ovary. Expressed at intermediate levels in the liver and pancreas and at low levels in the kidney and heart.
  • 数据库链接：

    HGNC: 11060

    OMIM: 601872

    KEGG: hsa:6542

    STRING: 9606.ENSP00000004531

    UniGene: Hs.448520