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SLC7A7 Antibody

  • 货号：
    CSB-PA892349LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse heart tissue, Mouse kidney tissue, Mouse brain tissue
      All lanes: SLC7A7 antibody at 3.5μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 56 kDa
      Observed band size: 56 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA892349LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA892349LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA892349LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品描述：

    The anti-SLC7A7 polyclonal antibody produced by CUSABIO is generated by immunizing rabbits with a truncated recombinant protein consisting of 325-382 amino acids of the human SLC7A7 protein. This unconjugated IgG isoform antibody has a purity of over 95% using protein G affinity chromatography purified.

    This SLC7A7 antibody is reactive to human and mouse samples and has been validated for use in ELISA, WB, IHC, and IF applications. The target protein SLC7A7, also known as cationic amino acid transporter 1 (CAT-1), is responsible for the transport of cationic amino acids such as arginine, lysine, and ornithine into cells, which is crucial for various biological processes and maintaining overall health.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLC7A7 Polyclonal antibody
  • Uniprot No.：
    Q9UM01
  • 基因名：
    SLC7A7
  • 别名：
    LAT3 antibody; LPI antibody; Monocyte amino acid permease 2 antibody; MOP-2 antibody; MOP2 antibody; SLC7A 7 antibody; Slc7a7 antibody; Solute carrier family 7 (cationic amino acid transporter; y+ system); member 7 antibody; Solute carrier family 7 member 7 antibody; y(+)L type amino acid transporter 1 antibody; y(+)L-type amino acid transporter 1 antibody; Y+L amino acid transporter 1 antibody; y+LAT-1 antibody; Y+LAT1 antibody; YLAT1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Y+L amino acid transporter 1 protein (325-382AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLC7A7 Antibody (CSB-PA892349LA01HU)，的标记方式是Non-conjugated。对于SLC7A7 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA892349LB01HU SLC7A7 Antibody, HRP conjugated ELISA
    FITC CSB-PA892349LC01HU SLC7A7 Antibody, FITC conjugated
    Biotin CSB-PA892349LD01HU SLC7A7 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes.
  • 基因功能参考文献：
    1. SLC7A7 overexpression decreased the apoptosis rate, increased the proportion of cells in the G1 phase, decreased the proportion of G2 cells, and significantly increased cell migration and invasion and increased intracellular arginine would activate mTOR, and induce apoptosis in SLC7A7 knockdown Jurkat cells. PMID: 30025393
    2. Confirmed by mRNA and protein expression, the amino acid transporters SLC7A7 and SLC38A5 showed marked differences between controls and intrauterine growth restriction/pre-eclampsia and were regulated by both diseases. In contrast, ABCA1 may play an exclusive role in the development of pre-eclempsia. PMID: 29499643
    3. At present, 51 kinds of SLC7A7 gene mutations causing lysinuric protein intolerance have been found worldwide, including insert (C.1384-1385 ins ACTA), delete (C.1185-1188 del TTCT) and point mutations (P.R410X, P.Y457X, P.R 468X, P.L124p, etc).3, 4 In our cases, there were two heterozygous mutations in the SLC7A7 gene of the two sisters: C.1387 del C and IVS4+1C>T, which has never been reported worldwide. PMID: 29058386
    4. The study reports a significant association between SLC7A7 rs12436190 and the risk of glioma in a Chinese population. PMID: 28510245
    5. the 1471 delTTCT mutation was identified in exon 9 in the homozygous state for all Tunisian patients with lysinuric protein Intolerance; The 1471 deITTCT mutation seems to be a common mutation of Tunisian population PMID: 26882824
    6. heteromerization of y+LAT1 and 4F2hc within the cell is not disrupted by any of the tested LPI mutations PMID: 23940088
    7. SLC7A7 genetic variants are associated with increase risk for glioma in a Chinese population. PMID: 23975734
    8. SLC7A7 plays a critical role in glioblastoma carcinogenesis and overexpression of SLC7A7 is correlated with worse outcomes in patients PMID: 23408368
    9. SLC7A7/y+LAT1 mutations lead to a defective phenotype of macrophages resulting in lysinuric Protein Intolerance. PMID: 22325938
    10. during differentiation of human monocytes from peripheral blood, SLC7A7 mRNA and system y(+)L activity are increased PMID: 21586674
    11. novel SLC7A7 mutations in patients with lysinuric protein intolerance PMID: 12402335
    12. expression levels and putative 5' promoter elements of the SLC7A7 gene PMID: 12589791
    13. putative multiheteromeric structure of both [4F2hc/y(+)LAT-1] and [4F2hc/y(+)LAT-2], and the interference between y(+)LAT-1 and y(+)LAT-2 proteins may have a role in the pathogenesis of lysinuric protein intolerance PMID: 15756301
    14. mutations of the SLC7A7 gene may have a role in lysinuric protein intolerance PMID: 15776427
    15. identified a novel alternative, TATA-box-containing promoter that plays a role in the tissue-specific regulation of SLC7A7 gene expression PMID: 17196863
    16. Mutation in the SLC7A7 gene is associated with lysinuric protein intolerance PMID: 17666782
    17. A review of the current knowledge of SLC7A7 mutations and their role in LPI pathogenesis. PMID: 17764084
    18. results suggest genomic rearrangement of SLC7A7 play more important role in lysinuric protein intolerance than has been reported; 3' region AluY repeat could be a recombination hot spot as it is involved in 38% of SLC7A7 rearranged chromosomes described PMID: 18716612

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  • 相关疾病：
    Lysinuric protein intolerance (LPI)
  • 亚细胞定位：
    Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Amino acid-polyamine-organocation (APC) superfamily, L-type amino acid transporter (LAT) (TC 2.A.3.8) family
  • 组织特异性：
    Highest expression in kidney and peripheral blood leukocytes. Weaker expression is observed in lung, heart, placenta, spleen, testis and small intestine. Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, ret
  • 数据库链接：

    HGNC: 11065

    OMIM: 222700

    KEGG: hsa:9056

    STRING: 9606.ENSP00000285850

    UniGene: Hs.513147