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SLC9A9 Antibody

  • 货号：
    CSB-PA003449
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of RAW264.7 cells using NHE-9 Polyclonal Antibody
    • Western Blot analysis of Jurkat K562 NIH-3T3 cells using NHE-9 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q8IVB4
  • 基因名：
    SLC9A9
  • 别名：
    5730527A11Rik antibody; 9930105B05 antibody; AI854429 antibody; FLJ35613 antibody; Na(+)/H(+) exchanger 9 antibody; Nbla00118 antibody; NHE 9 antibody; NHE-9 antibody; NHE9 antibody; Putative protein product of Nbla00118 antibody; SL9A9_HUMAN antibody; Slc9a9 antibody; Sodium/hydrogen exchanger 9 antibody; Sodium/proton exchanger NHE9 antibody; Solute carrier family 9 (sodium/hydrogen exchanger) isoform 9 antibody; Solute carrier family 9 (sodium/hydrogen exchanger) member 9 antibody; Solute carrier family 9 member 9 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human NHE-9.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell.
  • 基因功能参考文献：
    1. downregulation of miR-135a as a potential mechanism underlying the high NHE9 expression observed in subset of glioblastomas PMID: 29268774
    2. SLC9A9 is a sodium hydrogen exchanger present in the recycling endosome and highly expressed in the brain. PMID: 27439572
    3. SLC9A9 has an oncogenic function by being related to EGFR signaling, suggesting SLC9A9 may be a novel prognostic indicator and a therapeutic target in colorectal cancer PMID: 28476790
    4. Ectopic expression of NHE9 in human brain microvascular endothelial cells without external cues induced up-regulation of the transferrin receptor (TfR) and down-regulation of ferritin, leading to an increase in iron uptake PMID: 28130443
    5. Taken together, our findings demonstrate that NHE9 can be an effective predictor of chemoradiotherapy response in esophageal squamous cell carcinoma PMID: 25915159
    6. the expression of SLC9A9 can be a prognostic predictor for ESCC. PMID: 25835977
    7. SLC9A9 appears to influence the differentiation of T cells to a proinflammatory fate and may have a broader role in multiple sclerosis disease activity. There is an association between rs9828519(G) and nonresponse to IFNbeta treatment. PMID: 25914168
    8. find interesting gene expression changes in endosomal NHE6 and NHE9 in postmortem autism brains. PMID: 23508127
    9. Loss-of-function mutations in NHE9 may contribute to autistic phenotype by modulating synaptic membrane protein expression and neurotransmitter clearance. PMID: 24065030
    10. 33 directly measured and 13 derived glycosylation traits in 3533 individuals were identified and three novel gene association (MGAT5, B3GAT1 and SLC9A9) were identified using an additional European cohort. PMID: 21908519
    11. SLC9A9 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
    12. This review defines NHE6-9 as organellar NHEs that are fairly dynamic, implying that they are subjected to intracellular trafficking and thus they continuously shuttle between organelles and the plasma membrane. PMID: 21171650
    13. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20732626
    14. results suggest that SLC9A9 may be related to hyperactive-impulsive symptoms in AD/HD and the disruption of SLC9A9 may be responsible for the behavioral phenotype observed in the inversion family PMID: 20032819
    15. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    16. Observational study of gene-disease association. (HuGE Navigator) PMID: 20032819
    17. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 19268276
    18. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 18937294
    19. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 18821565
    20. Observational study of gene-disease association. (HuGE Navigator) PMID: 18649358

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  • 相关疾病：
    Autism 16 (AUTS16)
  • 亚细胞定位：
    Late endosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
  • 组织特异性：
    Ubiquitously expressed in all tissues tested. Expressed at highest levels in heart and skeletal muscle, followed by placenta, kidney, and liver. Expressed in the brain, in the medulla and spinal cord.
  • 数据库链接：

    HGNC: 20653

    OMIM: 608396

    KEGG: hsa:285195

    STRING: 9606.ENSP00000320246

    UniGene: Hs.302257