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SLCO1C1 Antibody

  • 货号：
    CSB-PA868355LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA868355LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA868355LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLCO1C1 Polyclonal antibody
  • Uniprot No.：
    Q9NYB5
  • 基因名：
    SLCO1C1
  • 别名：
    OAT-RP-5 antibody; OATP-14 antibody; OATP-F antibody; OATP1 antibody; OATP1C1 antibody; OATPRP5 antibody; Organic anion transporter F antibody; Organic anion transporter polypeptide-related protein 5 antibody; organic anion transporting polypeptide 14 antibody; Organic anion-transporting polypeptide 14 antibody; SLC21A14 antibody; Slco1c1 antibody; SO1C1_HUMAN antibody; solute carrier family 21 (organic anion transporter), member 14 antibody; Solute carrier family 21 member 14 antibody; Solute carrier organic anion transporter family member 1C1 antibody; solute carrier organic anion transporter family, member 1C1 antibody; Thyroxine transporter antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Solute carrier organic anion transporter family member 1C1 protein (297-348AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SLCO1C1 Antibody (CSB-PA868355LA01HU)，的标记方式是Non-conjugated。对于SLCO1C1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA868355LB01HU SLCO1C1 Antibody, HRP conjugated ELISA
    FITC CSB-PA868355LC01HU SLCO1C1 Antibody, FITC conjugated
    Biotin CSB-PA868355LD01HU SLCO1C1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a significant role in regulating T4 flux into and out of the brain.
  • 基因功能参考文献：
    1. The genetic variant, rs3794271, located within the PDE3A-SLCO1C1 locus was analyzed for correlation with treatment response using both the EULAR classification criteria and absolute change in (Delta)DAS28 scores as outcome measures correlated with anti-TNF response in a large UK rheumatoid arthritis cohort. PMID: 27180831
    2. We found a highly significant association between PDE3A-SLCO1C1 and the clinical response to TNF blockers PMID: 25403996
    3. The PDE3A-SLCO1C1 locus rs3794271 SNP showed a highly significant association with anti-TNF treatment response. PMID: 23651021
    4. Compared with the adult cerebral cortex, mRNAs encoding OATP1A2, OATP1C1, OATP3A1 variant 2, OATP4A1, LAT2 and CD98 were reduced in fetal cortex at different gestational ages, whilst mRNAs encoding MCT8, MCT10, OATP3A1 variant 1 and LAT1 were similar. PMID: 21486766
    5. The strong expression of MCT10 and OATP1C1 in the human hypothalamus indicates a possible role in the regulation of the hypothalamus-pituitary-thyroid axis. PMID: 21508134
    6. We have isolated and functionally characterized OATP-F. OATP-F has a more selective substrate preference and may play an important role in the disposition of thyroid hormones in brain and testis. PMID: 12351693
    7. OATP1C1 polymorphisms are associated with fatigue and depression, but do not explain differences in neurocognitive functioning or appreciation of LT4-LT3 combination therapy. PMID: 18410547
    8. OATP1C1 mediates transport of thyroid hormones and increases the access of these substrates to the intracellular active sites of the deiodinases with no effect of genetic variation PMID: 18566113
    9. OATP14 mRNA and protein are strongly enriched in mouse and rat cerebral microvessels but not in human microvessels. PMID: 18687783
    10. Protein is highly expressed in the intestine, kidney, cholangiocytes and the blood-brain barrier. PMID: 19290786
    11. Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18410547

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Organo anion transporter (TC 2.A.60) family
  • 组织特异性：
    Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels.
  • 数据库链接：

    HGNC: 13819

    OMIM: 613389

    KEGG: hsa:53919

    STRING: 9606.ENSP00000370964

    UniGene: Hs.47261