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SLK Antibody

  • 货号：
    CSB-PA291619
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from COLO205 cells, using SLK antibody.
    • Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue using SLK antibody.
    • Immunofluorescence analysis of HepG2 cells, using SLK antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SLK Polyclonal antibody
  • Uniprot No.：
    Q9H2G2
  • 基因名：
    SLK
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from C-terminal of Human SLK.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mediates apoptosis and actin stress fiber dissolution.
  • 基因功能参考文献：
    1. SLK interacts with Tpr and alpha-actinin-4 in cells, and these protein-protein interactions may control the subcellular localization and the biological activity of SLK. PMID: 26094769
    2. SLK activated ERMs, together with Galphai, are critical for the correct localization of LGN-NuMA force generator complexes and hence for proper spindle orientation. PMID: 24958772
    3. The fact that SLK (LOSK) phosphorylates only a minor isoform 1A of p150(Glued) suggests that transport and microtubule-organizing functions of dynactin are distinctly divided between the two isoforms PMID: 23985322
    4. v-Src-dependent down-regulation of the Ste20-like kinase SLK through casein kinase II. PMID: 16837460
    5. we show that a novel isoform of SPS1-related proline alanine-rich kinase (SPAK/STE20) is involved in this inflammatory signaling cascade PMID: 17321610
    6. Protein kinase LOSK is required for radial microtubule organization and for the proper localization of Golgi complex in various cell types. PMID: 18287541
    7. Studies define an interaction between Neu and SLK signaling in the regulation of cancer cell motility. PMID: 19525980

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 组织特异性：
    Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle.
  • 数据库链接：

    HGNC: 11088

    OMIM: 616563

    KEGG: hsa:9748

    STRING: 9606.ENSP00000358770

    UniGene: Hs.591922