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SMARCC1 Antibody

  • 货号：
    CSB-PA021806GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q92922
  • 基因名：
    SMARCC1
  • 别名：
    AI115498 antibody; BAF 155 antibody; BAF155 antibody; BRG 1 associated factor 155 antibody; BRG1 associated factor 155 antibody; BRG1-associated factor 155 antibody; Chromatin remodeling complex BAF155 subunit antibody; CRACC 1 antibody; CRACC1 antibody; Mammalian chromatin remodeling complex BRG 1 associated factor 155 antibody; Mammalian chromatin remodeling complex BRG1 associated factor 155 antibody; Rsc 8 antibody; Rsc8 antibody; SMARC C1 antibody; SMARCC 1 antibody; SMARCC1 antibody; SMRC1_HUMAN antibody; SRG 3 antibody; SRG3 antibody; SWI 3 antibody; SWI/SNF complex 155 kDa subunit antibody; SWI/SNF complex subunit SMARCC1 antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin c1 antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 1 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 antibody; SWI3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SMARCC1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
  • 基因功能参考文献：
    1. Study found SMARCC1 as a direct target of miR-202-5p and promoted the growth and metastasis of colorectal carcinoma (CRC) cells. Furthermore, SMARCC1 could reverse the inhibitory effect of miR-202-5p on growth and metastasis of CRC cells. PMID: 30144500
    2. our data showed that Swi3 strongly affects haem/oxygen-dependent activation of respiration gene promoters whereas Swi2 affects only the basal, haem-independent activities of these promoters. using computational analysis and RNAi knockdown, we showed that the mammalian Swi3 BAF155 and BAF170 regulate respiration in HeLa cells. PMID: 27190130
    3. Results show the secondary structure of SWIRM domain of BAF155 consists of five alpha-helices forming a typical histone fold for DNA interactions. PMID: 23996527
    4. we identify BAF155 as a substrate for arginine methyltransferase CARM1. PMID: 24434208
    5. Wwp2 acts as a ubiquitin ligase of SRG3. PMID: 24365151
    6. miR-320c regulates the resistance of pancreatic cancer cells to gemcitabine through SMARCC1. PMID: 23799850
    7. loss of BAF155 expression represents another mechanism for inactivation of SWI/SNF complex activity in the development in human cancer. PMID: 22139574
    8. Data show that the mechanism of BAF155-mediated stabilization of BAF57 involves blocking its ubiquitination by preventing interaction with TRIP12. PMID: 20829358
    9. protein levels of BAF155/170 dictate the maximum cellular amount of BAF57 PMID: 16199878
    10. Constitutive expression of SRG3 inhibits positive selection processes in T-cell receptor transgenic mice. PMID: 17513758
    11. An increased expression of SMARCC1 protein was found in prostate cancer positively correlated with tumour dedifferentiation, progression, metastasis and time to recurrence. PMID: 18581278
    12. patients with tumours displaying high levels of CBFB and SMARCC1 proteins had a significantly better overall survival rate than patients with low levels PMID: 19156145

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    SMARCC family
  • 组织特异性：
    Expressed in brain, heart, muscle, placenta, lung, liver, muscle, kidney and pancreas.
  • 数据库链接：

    HGNC: 11104

    OMIM: 601732

    KEGG: hsa:6599

    STRING: 9606.ENSP00000254480

    UniGene: Hs.476179