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SMC2 Antibody

  • 货号：
    CSB-PA021814LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of HepG2 cells with CSB-PA021814LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SMC2 Polyclonal antibody
  • Uniprot No.：
    O95347
  • 基因名：
    SMC2
  • 别名：
    CAP E antibody; CAPE antibody; Chromosome associated protein E antibody; Chromosome-associated protein E antibody; FLJ10093 antibody; hCAP E antibody; hCAP-E antibody; hCAPE antibody; PRO0324 antibody; SMC 2 antibody; SMC protein 2 antibody; SMC-2 antibody; SMC2 antibody; SMC2 L1 antibody; SMC2_HUMAN antibody; SMC2L1 antibody; Structural maintenance of chromosomes (SMC) family member chromosome associated protein E antibody; Structural maintenance of chromosomes 2 antibody; Structural maintenance of chromosomes 2 like 1 antibody; Structural maintenance of chromosomes 2 yeast like 1 antibody; Structural maintenance of chromosomes protein 2 antibody; XCAP E homolog antibody; XCAP-E homolog antibody; XCAPE homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Structural maintenance of chromosomes protein 2 protein (861-968AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SMC2 Antibody (CSB-PA021814LA01HU)，的标记方式是Non-conjugated。对于SMC2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA021814LB01HU SMC2 Antibody, HRP conjugated ELISA
    FITC CSB-PA021814LC01HU SMC2 Antibody, FITC conjugated
    Biotin CSB-PA021814LD01HU SMC2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
  • 基因功能参考文献：
    1. SMC2 (or the condensin complex) is a novel molecular target for the treatment of MYCN-amplified neuroblastoma. PMID: 24553121
    2. SMC2 gene is altered by both frameshift mutation and loss of expression in gastric and colorectal cancers, suggesting that SMC2 gene alterations might be involved in pathogenesis of these cancers PMID: 24483990
    3. WNT signaling can directly activate SMC2 transcription as a key player in the mitotic cell division machinery. PMID: 23095742
    4. Studies indicate that tagged SMC2 subunit of the condensin complex with the streptavidin-Binding Peptide optimising efficacious use of this tag for protein analysis. PMID: 21194474
    5. human SMC2 hinge domain with short coiled coils was cloned, expressed, purified and crystallized in the orthorhombic space group C222 in native and SeMet-derivatized forms PMID: 20823528

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
  • 蛋白家族：
    SMC family, SMC2 subfamily
  • 数据库链接：

    HGNC: 14011

    OMIM: 605576

    KEGG: hsa:10592

    STRING: 9606.ENSP00000286398

    UniGene: Hs.119023