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SMYD1 Antibody

  • 货号：
    CSB-PA847673ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Histone-lysine N-methyltransferase SMYD1 antibody at 2μg/ml
      Lane 1: Mouse heart tissue
      Lane 2: 293T whole cell lysate
      Lane 3: Mouse skeletal muscle tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 57 kDa
      Observed band size: 57 kDa
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA847673ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA847673ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SMYD1 Polyclonal antibody
  • Uniprot No.：
    Q8NB12
  • 基因名：
    SMYD1
  • 别名：
    BOP antibody; CD8 beta opposite antibody; CD8b opposite antibody; Histone lysine N methyltransferase SMYD1 antibody; KMT3D antibody; SET and MYND domain containing 1 antibody; SET and MYND domain-containing protein 1 antibody; SMYD1 antibody; SMYD1_HUMAN antibody; Zinc finger MYND domain containing 18 antibody; ZMYND18 antibody; ZMYND22 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Histone-lysine N-methyltransferase SMYD1 protein (1-350AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.
  • 基因功能参考文献：
    1. We present genetic and statistical evidence that the R320Q substitution in SMYD1 underlies an inherited form of the AnWj-negative blood group phenotype. The mechanism by which the mutation leads to this phenotype remains to be determined. PMID: 29956848
    2. SMYD1 serves as an Serum Response Factor-interacting protein, enhances Serum Response Factor DNA binding activity, and is required for endothelial cell migration and tube formation to regulate angiogenesis. PMID: 26799706
    3. SMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma. PMID: 25644430
    4. effects of gene mutations on ventricular development PMID: 12858532
    5. HDGF functions as a transcriptional repressor of the SMYD1 gene through interaction with the transcriptional corepressor CtBP. PMID: 19162039

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily
  • 组织特异性：
    Expression seems mostly restricted to heart and skeletal muscle.
  • 数据库链接：

    HGNC: 20986

    OMIM: 606846

    KEGG: hsa:150572

    STRING: 9606.ENSP00000393453

    UniGene: Hs.516176