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SNAP91 Antibody

  • 货号：
    CSB-PA021876DSR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SNAP91 Polyclonal antibody
  • Uniprot No.：
    O60641
  • 基因名：
    SNAP91
  • 别名：
    SNAP91 antibody; KIAA0656Clathrin coat assembly protein AP180 antibody; 91 kDa synaptosomal-associated protein antibody; Clathrin coat-associated protein AP180 antibody; Phosphoprotein F1-20 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Clathrin coat assembly protein AP180 protein (628-907AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats.
  • 基因功能参考文献：
    1. intrinsically disordered domains are highly potent drivers of membrane curvature PMID: 26204806
    2. To sustain efficient neurotransmission and synaptic vesicle formation, AP180 and VAMP2 are required. PMID: 26412491
    3. unique mechanism of SNARE motif-dependent endocytic sorting and identify the ANTH domain proteins AP180 and CALM as cargo-specific adaptors for synaptobrevin endocytosis PMID: 21808019
    4. AP180 is significantly decreased in the hippocampus of Alzheimer's disease patients and in hippocampal neurons of transgenic mice. PMID: 20847448
    5. AP180 had an overall expression similar to synaptophysin, the immunoreactivity for the two proteins did not always co-localize. PMID: 12493563

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  • 亚细胞定位：
    Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    PICALM/SNAP91 family
  • 数据库链接：

    HGNC: 14986

    OMIM: 607923

    KEGG: hsa:9892

    STRING: 9606.ENSP00000358708

    UniGene: Hs.368046