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SNRK Antibody

  • 货号：
    CSB-PA868301NA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: 293T whole cell lysate, K562 whole cell lysate
      All lanes: SNRK antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 85, 28 kDa
      Observed band size: 85 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SNRK Polyclonal antibody
  • Uniprot No.：
    Q9NRH2
  • 基因名：
    SNRK
  • 别名：
    DKFZp779A1866 antibody; FLJ20224 antibody; HSNFRK antibody; KIAA0096 antibody; SNF related kinase antibody; SNF related serine/threonine protein kinase antibody; SNF-related serine/threonine-protein kinase antibody; SNF1 related kinase antibody; SNF1-related kinase antibody; SNFRK antibody; Snrk antibody; SNRK_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Peptide sequence from Human SNF-related serine/threonine-protein kinase protein (340-360AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SNRK Antibody (CSB-PA868301NA01HU)，的标记方式是Non-conjugated。对于SNRK Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA868301NB01HU SNRK Antibody, HRP conjugated ELISA
    FITC CSB-PA868301NC01HU SNRK Antibody, FITC conjugated
    Biotin CSB-PA868301ND01HU SNRK Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.
  • 基因功能参考文献：
    1. Study shows that TRIB3 binds to SNRK, and downregulates UCP3 through PPARalpha. SNRK is increased in cardiomyopathy patients, and SNRK reduces infarct size after ischaemia/reperfusion. SNRK also decreases cardiac cell death in a UCP3-dependent manner. PMID: 28117339
    2. Report the crystal structure of an N-terminal SNRK fragment containing kinase and adjacent ubiquitin-associated (UBA) domains. This structure shows that the UBA domain binds between the N- and C-lobes of the kinase domain. The mode of UBA binding in SNRK largely resembles that in AMPK and brain specific kinase (BRSK), however, unique interactions play vital roles in stabilizing the KD-UBA interface of SNRK. PMID: 29061304
    3. SNRK in cardiomyocytes is responsible for maintaining cardiac metabolic homeostasis, which is mediated in part by ROCK, and alteration of this homeostasis influences cardiac function in the adult heart. PMID: 27780848
    4. Differential expression of SNRK in early versus late stage disease suggests specific roles for SNRK in ovarian cancer metastasis. PMID: 28722495
    5. SNRK inhibits colon cancer cell proliferation through calcyclin-binding protein up-regulation and beta-catenin degradation, which results in reduced proliferation signaling. PMID: 22874833
    6. These findings reveal a novel function for SNRK in the regulation of colon cancer cell proliferation and beta-catenin signaling. PMID: 22874833
    7. SNRK could mediate some of the physiological effects of LKB1 PMID: 15733851

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family
  • 组织特异性：
    Expressed in hematopoietic progenitor cells and leukemic cell lines. Weakly expressed in the testis.
  • 数据库链接：

    HGNC: 30598

    OMIM: 612760

    KEGG: hsa:54861

    STRING: 9606.ENSP00000296088

    UniGene: Hs.476052