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SNX14 Antibody

  • 货号：
    CSB-PA806844LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA806844LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA806844LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA806844LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SNX14 Polyclonal antibody
  • Uniprot No.：
    Q9Y5W7
  • 基因名：
    SNX14
  • 别名：
    MGC13217 antibody; RGS-PX2 antibody; RP11-321N4.2 antibody; Snx14 antibody; SNX14_HUMAN antibody; Sorting nexin 14 antibody; Sorting nexin-14 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Sorting nexin-14 protein (601-893AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SNX14 Antibody (CSB-PA806844LA01HU)，的标记方式是Non-conjugated。对于SNX14 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA806844LB01HU SNX14 Antibody, HRP conjugated ELISA
    FITC CSB-PA806844LC01HU SNX14 Antibody, FITC conjugated
    Biotin CSB-PA806844LD01HU SNX14 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking. Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes. Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)).
  • 基因功能参考文献：
    1. Here we report on a child with a novel missense mutation in the SNX14 gene that appears to be debilitating for protein conformation, function and review the previously reported cases from 15 families PMID: 27913285
    2. A unique ataxia syndrome due to biallelic SNX14 mutations leading to lysosome-autophagosome dysfunction. PMID: 25848753
    3. SNX19 and SNX14 PX domains reveal key differences in spatial control of RGS-PX proteins in cell signaling and trafficking. PMID: 25148684
    4. Mutations in SNX14 cause a distinctive autosomal-recessive cerebellar ataxia and intellectual disability syndrome. PMID: 25439728
  • 相关疾病：
    Spinocerebellar ataxia, autosomal recessive, 20 (SCAR20)
  • 亚细胞定位：
    Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cell projection, dendrite.
  • 蛋白家族：
    Sorting nexin family
  • 组织特异性：
    Widely expressed both in fetal and adult tissues.
  • 数据库链接：

    HGNC: 14977

    OMIM: 616105

    KEGG: hsa:57231

    STRING: 9606.ENSP00000313121

    UniGene: Hs.485871