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SOX12 Antibody

  • 货号：
    CSB-PA050122
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O15370
  • 基因名：
    SOX12
  • 别名：
    Homo sapiens SRY (sex determining region Y) box 12 antibody; Protein SOX-22 antibody; SOX 12 antibody; SOX 12 protein antibody; SOX 22 antibody; SOX 22 protein antibody; sox12 antibody; SOX12 protein antibody; SOX12_HUMAN antibody; SOX22 antibody; SOX22 protein antibody; SRY (sex determining region Y) box 12 antibody; SRY (sex determining region Y) box 22 antibody; SRY box 12 antibody; SRY box 22 antibody; SRY related HMG box gene 22 antibody; Transcription factor SOX 12 antibody; Transcription factor Sox-12 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Sox-12.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor that binds to DNA at the consensus sequence 5'-ACCAAAG-3'. Acts as a transcriptional activator. Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation. Involved in the differentiation of naive CD4-positive T-cells into peripherally induced regulatory T (pT reg) cells under inflammatory conditions. Binds to the promoter region of the FOXP3 gene and promotes its transcription, and might thereby contribute to pT reg cell differentiation in the spleen and lymph nodes during inflammation. Plays a redundant role with SOX4 and SOX11 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis.
  • 基因功能参考文献：
    1. SOX12 can increase the expression of CDK4 and IGF2BP1, which confer malignant phenotypes to HepatocellularCarcinoma. PMID: 28975985
    2. Data found that, in hepatocellular carcinoma (HCC) cell lines, Sox12+ HCC cells generated significantly more tumor spheres in culture, were more chemo-resistant to cisplatin, were detected in circulation more frequently, and formed distal tumor more frequently compared to Sox12- HCC cells. Moreover, Sox12 appeared to functionally contribute to the stemness of HCC cells. PMID: 29127951
    3. SOX12 may be involved in leukemia progression by regulating the expression of beta-catenin and then interfering with TCF/Wnt pathway, which may be a target for AML. PMID: 27858992
    4. Up-regulated Sox12 induced by FoxQ1 promotes hepatocellular carcinoma invasion and metastasis by transactivating Twist1 and FGFBP1 expression. PMID: 25704764
    5. This genome-wide screen has identified two novel metastatic suppressors: TMED3 and SOX12, the knockdown of which increases metastatic growth after direct seeding. PMID: 24920608
    6. SOX12 and NRSN2 were identified as candidate genes that may be involved in the developmental defects in 20p13 microdeletion. PMID: 24019301
    7. Functional analysis of the orthologous mouse gene. PMID: 185058

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed most abundantly in the CNS. Expressed in the heart, pancreas, thymus, testis and ovary. Weakly expressed in brain, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, small intestine, colon, and peripheral blood lymphocytes.
  • 数据库链接：

    HGNC: 11198

    OMIM: 601947

    KEGG: hsa:6666

    UniGene: Hs.43627