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SPAG11A Antibody

  • 货号：
    CSB-PA022460GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q6PDA7
  • 基因名：
    SPAG11A
  • 别名：
    SPAG11A antibody; EP2 antibody; HE2 antibody; Sperm-associated antigen 11A antibody; Human epididymis-specific protein 2 antibody; He2 antibody; Protein EP2 antibody; Sperm antigen HE2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human SPAG11A
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May have antimicrobial activity. May also play a role sperm maturation, storage, and protection.
  • 基因功能参考文献：
    1. we report the three dimensional structure of the human SPAG11B proteins and their C-terminal peptides. web-based hydropathy, amphipathicity, and topology (WHAT) analyses and grand average of hydropathy PMID: 25573789
    2. Isoform C of SPAG11B encodes a peptide with antimicrobial activity against E. coli. PMID: 16411022
    3. Combination of two proteins, SPAG11B and TEX101, can be used for differential diagnosis of azoospermia PMID: 21933954
    4. SPAG11B/D is both a substrate and a potent inhibitor of TPSAB1 activity. PMID: 19535787
    5. HE2 peptides were detected in human epididymal epithelium, epididymal fluid, and ejaculate PMID: 12193388
    6. HE2 transcriptional and translational products normally expressed in the caput epididymidis were not affected by vasectomy. PMID: 14662784
    7. EP2 expression is more widespread in male reproductive tract than realized previously. Activity of every EP2 variant tested is antibacterial. Further investigation may reveal additional roles for EP2 peptides in primate male reproductive tract. PMID: 15229135
    8. In the chimpanzee epididymis, several mRNA HE2/EP2 variants are produced. Of these, three cDNAs code for two different protein sequences that have a cysteine distribution characteristic for beta-defensins. PMID: 10819450
    9. The human HE2/EP2 gene is the fusion product of two ancestral beta-defensin genes. During its evolution, the gene has acquired additional exons whose inclusion produces new message variants that encode peptides unrelated to defensins. PMID: 11259252

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    SPAG11 family
  • 数据库链接：

    HGNC: 33342

    OMIM: 606560

    KEGG: hsa:653423

    STRING: 9606.ENSP00000381480

    UniGene: Hs.2717