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SPAG8 Antibody

  • 货号：
    CSB-PA022469GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q99932
  • 基因名：
    SPAG8
  • 别名：
    BS 84 antibody; CILD28 antibody; HSD 1 antibody; HSD-1 antibody; HSD1 antibody; hSMP1 antibody; MGC26201 antibody; MH SPAG8 antibody; OTTHUMP00000021352 antibody; OTTMUSP00000032209 antibody; SMP-1 antibody; SMP1 antibody; SPAG3 antibody; SPAG8 antibody; SPAG8_HUMAN antibody; Sperm associated antigen 8 antibody; Sperm associated antigen 8 like protein antibody; Sperm membrane protein 1 antibody; Sperm membrane protein BS-84 antibody; Sperm-associated antigen 8 antibody; Testicular tissue protein Li 177 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human SPAG8
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau. Involved in the acrosome reaction and in binding of sperm to the zona pellucida. Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.
  • 基因功能参考文献：
    1. Results indicate that SPAG8 acts as a regulator of ACT and plays an important role in CREM-ACT-mediated gene transcription during spermatogenesis. PMID: 20488182
    2. The antibody of this recombinant protein inhibits the mouse acrosome reaction and prmits mouse sperm-zona pellucida binding. PMID: 17187156
    3. Sperm associated antigen 8 might be involved in the regulation of cell cycle by changing the phosphorylation level of Tyr15 on CDC2 Protein Kinase. PMID: 19548270
  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族：
    SPAG8 family
  • 组织特异性：
    Expressed in testis (germ cells), but not in liver, kidney, prostate and small intestine.
  • 数据库链接：

    HGNC: 14105

    OMIM: 605731

    KEGG: hsa:26206

    STRING: 9606.ENSP00000340982

    UniGene: Hs.256747