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SPARCL1 Antibody

  • 货号：
    CSB-PA268589
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA268589(SPARCL1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA268589(SPARCL1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q14515
  • 基因名：
    SPARCL1
  • 别名：
    Ecm2 antibody; Extracellular matrix protein 2 antibody; Hevin antibody; High endothelial venule protein antibody; MAST 9 antibody; mast9 antibody; Matrix glycoprotein Sc1 antibody; PIG33 antibody; proliferation inducing protein 33 antibody; RAGS1 antigen antibody; SC1 antibody; SPARC like 1 antibody; SPARC-like protein 1 antibody; Sparcl1 antibody; SPRL1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human SPARCL1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. SC1 levels were independently associated with ischemic stroke severity evaluated by the NIHSS. PMID: 29102542
    2. The results of this study suggest that the SPARCL1 accelerates Alzheimer's Disease pathogenesis and thus link neuroinflammation with widespread changes in brain structure and function during aging. PMID: 29154276
    3. The present study demonstrated that the expression of SPARCL1 was downregulated in renal cell carcinoma (RCC) cells and tissues, however, the overexpression of SPARCL1 inhibited RCC cell migration and invasion. PMID: 28944877
    4. This study demonstrated the SPARCL1-containing neurons in the human brainstem and sensory ganglion. PMID: 27357901
    5. tumor endothelial cells heterogeneity is regulated by SPARCL1, which promotes the cell quiescence and vessel homeostasis contributing to the favorable prognoses associated with Th1-tumor microenvironments colorectal carcinomas. PMID: 27721236
    6. SPARCL1 is involved in the tumorigenesis of hilar cholangiocarcinoma and may serve as a novel molecular biomarker for patients' outcome. PMID: 26490986
    7. Androgen-Regulated SPARCL1 in the Tumor Microenvironment Inhibits Metastatic Progression PMID: 26294211
    8. SPARCL1 expression did not inhibit tumor cell proliferation in vitro. By contrast, SPARCL1 did suppress tumor cell migration and invasiveness in vitro and tumor metastatic growth in vivo, conferring improved survival in xenograft mouse models PMID: 23916135
    9. radiotherapy causes an increase in SPARCL1 expression; SPARCL1 may have a role in survival in rectal cancer patients PMID: 24661672
    10. SPARCL1 functions as a tumor suppressor promoting differentiation possibly via MET, which inhibits the aggressiveness of colorectal cancers PMID: 22891198
    11. Sparc-like protein 1 expression correlates with glioma grade, suggesting the possible role for this protein in the progression of this malignancy. PMID: 22909274
    12. SPARCL1 is a potent regulator of cell migration/invasion and its loss is independently associated with prostate cancer recurrence. PMID: 22927397
    13. Data suggest that the expression of SPARCL1 protein might be a valuable biomarker for early diagnosis in colorectal cancers and further predicting patients' prognosis. PMID: 21887554
    14. Down-regulated SPARCL1 is associated with gastric cancer. PMID: 22161898
    15. Data suggest that SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are potential prognostic markers in colorectal cancer. PMID: 21528083
    16. Overall, these results suggested that the C-t of hevin contains important determinants for interaction with myocilin. PMID: 16316624
    17. hevin can modulate the structure of dermal extracellular matrix, specifically by its regulation of decorin levels and collagen fibril assembly PMID: 16844696
    18. Despite proteomic studies in CSF from MS patients suggested an important role for SPARCL1 in the development of the disease, SPARCL1 gene does not appear to act as susceptibility factor for MS in the population investigated here. PMID: 17825989
    19. A transgenic mouse model in which SPARCL1 is expressed in radial glia provides a novel in vivo system for evaluating the role of SPARCL1 in brain development and function. PMID: 18381651

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    SPARC family
  • 组织特异性：
    Highly expressed in lymph node, brain, heart, lung, skeletal muscle, ovary, small intestine, and colon, with lower levels in placenta, pancreas, testis, spleen, and thymus, and no expression in kidney, liver, and peripheral blood leukocytes.
  • 数据库链接：

    HGNC: 11220

    OMIM: 606041

    KEGG: hsa:8404

    STRING: 9606.ENSP00000282470

    UniGene: Hs.62886