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SPATA18 Antibody

  • 货号：
    CSB-PA186712
  • 规格：
    ￥1100
  • 图片：
    • Gel: 8%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA186712(SPATA18 Antibody) at dilution 1/250 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 5 minutes
  • 其他：

产品详情

  • Uniprot No.：
    Q8TC71
  • 基因名：
    SPATA18
  • 别名：
    1700067I02Rik antibody; FLJ32906 antibody; MGC93900 antibody; Mieap antibody; mitochondria eating protein antibody; SPATA18 antibody; Spermatogenesis associated 18 antibody; spermatogenesis associated 18 homolog (rat) antibody; Spermatogenesis associated protein 18 antibody; Spermatogenesis-associated protein 18 antibody; SPETEX1 antibody; SPT18_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human SPATA18
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.
  • 基因功能参考文献：
    1. The physical interaction of Mieap, BNIP3 and NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. PMID: 22292033
    2. Mieap induces intramitochondrial lysosome-like organella that plays a critical role in mitochondrial quality control by eliminating oxidized mitochondrial proteins PMID: 21264221
    3. Mieap induced vacuole-like structures (designated as MIV for Mieap-induced vacuole), which engulfed and degraded the unhealthy mitochondria by accumulating lysosomes PMID: 21264228
    4. show that SPATA18 transcription is induced by p53 in a variety of cell types of both human and mouse origin PMID: 21300779
    5. beta-sarcoglycan and SPATA18 may have a role in limb-girdle muscular dystrophy type 2E PMID: 16088906

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  • 亚细胞定位：
    Cytoplasm. Mitochondrion outer membrane.
  • 蛋白家族：
    MIEAP family
  • 数据库链接：

    HGNC: 29579

    OMIM: 612814

    KEGG: hsa:132671

    STRING: 9606.ENSP00000295213

    UniGene: Hs.527090