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SPG21 Antibody

  • 货号：
    CSB-PA889158LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA889158LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA889158LA01HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA889158LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SPG21 Polyclonal antibody
  • Uniprot No.：
    Q9NZD8
  • 基因名：
  • 别名：
    SPG21 antibody; ACP33 antibody; BM-019 antibody; GL010 antibody; Maspardin antibody; Acid cluster protein 33 antibody; Spastic paraplegia 21 autosomal recessive Mast syndrome protein antibody; Spastic paraplegia 21 protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Maspardin protein (1-308AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SPG21 Antibody (CSB-PA889158LA01HU)，的标记方式是Non-conjugated。对于SPG21 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA889158LB01HU SPG21 Antibody, HRP conjugated ELISA
    FITC CSB-PA889158LC01HU SPG21 Antibody, FITC conjugated
    Biotin CSB-PA889158LD01HU SPG21 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a role as a negative regulatory factor in CD4-dependent T-cell activation.
  • 基因功能参考文献：
    1. HBV X gene enhanced SPG21 gene promoter activity, SPG21 mRNA expression and SPG21 protein production in HepG2 cells in a dose-dependent manner. PMID: 21205478
    2. frameshift results in the premature termination of the encoded product, which is designated "maspardin" (Mast syndrome, spastic paraplegia, autosomal recessive with dementia) PMID: 14564668
    3. Data report that maspardin localizes prominently to cytoplasm as well as to membranes, possibly at trans-Golgi network/late endosomal compartments, and that maspardin interacts with the aldehyde dehydrogenase ALDH16A1. PMID: 19184135
  • 相关疾病：
    Spastic paraplegia 21, autosomal recessive (SPG21)
  • 亚细胞定位：
    Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Partially localized in the cytosol but also accumulated on an intracellular vesicular compartment. Colocalizes with CD4 on endosomal/trans-Golgi network.
  • 蛋白家族：
    AB hydrolase superfamily
  • 组织特异性：
    Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in J.CaM1.6, HuT 78 and HeLa cell lines (at protein level).
  • 数据库链接：

    HGNC: 20373

    OMIM: 248900

    KEGG: hsa:51324

    STRING: 9606.ENSP00000204566

    UniGene: Hs.242458