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SPRR1B Antibody

  • 货号：
    CSB-PA022611LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA022611LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SPRR1B Polyclonal antibody
  • Uniprot No.：
    P22528
  • 基因名：
    SPRR1B
  • 别名：
    14.9 kDa pancornulin antibody; Cornifin antibody; Cornifin B antibody; Cornifin-B antibody; CornifinB antibody; GADD33 antibody; MGC61901 antibody; Small proline rich protein IB antibody; Small proline-rich protein IB antibody; SPR-IB antibody; SPR1B_HUMAN antibody; SPRIB antibody; SPRR1 antibody; SPRR1B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cornifin-B protein (1-89AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SPRR1B Antibody (CSB-PA022611LA01HU)，的标记方式是Non-conjugated。对于SPRR1B Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA022611LB01HU SPRR1B Antibody, HRP conjugated ELISA
    FITC CSB-PA022611LC01HU SPRR1B Antibody, FITC conjugated
    Biotin CSB-PA022611LD01HU SPRR1B Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage.
  • 基因功能参考文献：
    1. Expression of SPRR1 and of SPRR2A is increased in mucosal samples from patients with chronic rhinosinusitis and appeared as a downstream result of TNF alpha modulation, which possibly resulted in epithelial barrier dysfunction. PMID: 28859701
    2. Levels SPRR1B proteins were significantly higher in AD skin compared with the levels of these proteins in the skin of healthy subjects. PMID: 27304082
    3. expression of SPRR1B is upregulated in oral CSCs/CICs and SPRR1B has a role in cell growth by suppression of RASSF4 PMID: 23954638
    4. BMK1 (ERK5) regulates squamous differentiation marker SPRR1B transcription in Clara-like H441 cells. PMID: 12091247
    5. SPRR1B expression pattern in nonsquamous tumors; findings indicate SPRR1B likely coupled to signals responsible for withdrawal from the proliferative state; overexpression for prolonged periods may disrupt normal progression of mitosis PMID: 12832281
    6. SPRR1B is a valid biomarker for the study of the molecular mechanisms of squamous metaplasia. There is a definitive link between inflammation and squamous metaplasia in autoimmune-mediated dry eye disease PMID: 18172072

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Cornifin (SPRR) family
  • 组织特异性：
    Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea.
  • 数据库链接：

    HGNC: 11260

    OMIM: 182266

    KEGG: hsa:6699

    STRING: 9606.ENSP00000306461

    UniGene: Hs.1076