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SPTBN1 Antibody

  • 货号：
    CSB-PA733819LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA733819LA01HU diluted at 1:200 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA733819LA01HU diluted at 1:200 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of 293 cells with CSB-PA733819LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SPTBN1 Polyclonal antibody
  • Uniprot No.：
    Q01082
  • 基因名：
    SPTBN1
  • 别名：
    Beta G spectrin antibody; Beta II spectrin antibody; Beta spectrin 2 antibody; Beta spectrin II antibody; Beta-II spectrin antibody; betaSpII antibody; brain 1 antibody; ELF antibody; Embryonic liver beta fodrin antibody; Fodrin beta chain antibody; non-erythroid beta chain 1 antibody; Spectrin antibody; Spectrin beta chain antibody; Spectrin, beta, non erythrocytic 1 antibody; Spectrin, non erythroid beta chain 1 antibody; SPTB2 antibody; SPTB2_HUMAN antibody; SPTBN1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Spectrin beta chain, non-erythrocytic 1 protein (2096-2256AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SPTBN1 Antibody (CSB-PA733819LA01HU)，的标记方式是Non-conjugated。对于SPTBN1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA733819LB01HU SPTBN1 Antibody, HRP conjugated ELISA
    FITC CSB-PA733819LC01HU SPTBN1 Antibody, FITC conjugated
    Biotin CSB-PA733819LD01HU SPTBN1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
  • 基因功能参考文献：
    1. c-Met overexpression, HER-2 gene amplification, and SPTBN1-ALK gene fusion can coexist in lung adenocarcinoma and may become a potential biomarker of cancer refractory to crizotinib, chemotherapy, and radiotherapy as well as of a relatively poor prognosis. PMID: 27496196
    2. Subjects whose head and neck tumors expressed spectrin were 4.60 times more likely (hazard ratio; 95% confidence interval: 1.88-11.25) to die at any given time when compared with those without spectrin (P = .001). PMID: 27095047
    3. TGF-beta1 and ELF protein are potential and reliable biomarkers for predicting prognosis in HCC patients after hepatic resection. PMID: 25880619
    4. betaII spectrin is critical for normal myocyte electric activity. Dysfunction in the betaII spectrin-dependent cytoskeleton in cardiomyocytes contributes to human arrhythmia. PMID: 25632041
    5. decreased SPTBN1 and kallistatin gene expression associated with decreased relapse-free survival in hepatocellular carcinoma PMID: 25307947
    6. in human HCC tissues, SPTBN1 expression correlated negatively with expression levels of STAT3, ATF3, and CREB2; SMAD3 expression correlated negatively with STAT3 expression PMID: 25096061
    7. genetic association study in population of 1,012 Han women in China: Data suggest that an SNP in SPTBN1 (rs11898505) is associated with osteoporotic fractures and bone mineral density of lumbar spine in aging women. PMID: 22798246
    8. Results suggest that epigenetic silencing of SPTBN1 (beta2SP) is a new potential causal factor in BWS patients. PMID: 20739274
    9. reduced SPTBN1 expression correlated with shorter survival of pancreatic cancer patients, suggesting a tumor suppressor function of this gene PMID: 20886430
    10. High affinity and slow overall kinetics of association/dissociation of beta II-spectrin may suit it well to a role in strengthening cell junctions and providing stable anchorage for transmembrane proteins at points specified by cell-adhesion molecules. PMID: 12820899
    11. Quantitative analysis of erythrocyte membrane proteins revealed increase in beta-spectrin from patients with homozygous and heterozygous forms of beta-thalassemia. PMID: 15310273
    12. ankyrin-G and beta(2)-spectrin are functional partners in biogenesis of the lateral membrane of epithelial cells PMID: 17074766
    13. because both the T2159E mutant and the wild-type allow neuritogenesis, we conclude that the short C-terminal betaII-spectrin is phosphorylated during this process PMID: 17088250
    14. TGF-beta signaling and Smad adaptor embryonic liver fodrin (ELF) suppress human hepatocarcinogenesis, potentially through cyclin D1 deregulation. PMID: 17546056
    15. E-cadherin thus requires both ankyrin-G and beta-2-spectrin for its cellular localization in early embryos as well as cultured epithelial cells. PMID: 17620337
    16. Our results therefore indicate the importance of N-terminal region for lipid-binding activity of the beta-spectrin ankyrin-binding domain and its substantial role in maintaining the spectrin-based skeleton distribution. PMID: 17716929
    17. Characterization of the 2p21 breakpoint identified the SPTBN1 gene in myeloproliferative disorders. PMID: 18262053
    18. ELF, a TGF-beta adaptor and signaling molecule, functions as a critical adaptor protein in TGF-beta modulation of angiogenesis as well as cell cycle progression. PMID: 18704924

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, M line.; [Isoform 2]: Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Spectrin family
  • 组织特异性：
    Isoform 2 is present in brain, lung and kidney (at protein level).
  • 数据库链接：

    HGNC: 11275

    OMIM: 182790

    KEGG: hsa:6711

    STRING: 9606.ENSP00000349259

    UniGene: Hs.503178