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SPTLC2 Antibody

  • 货号：
    CSB-PA022640LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: SPTLC2 antibody at 12µg/ml
      Lane 1: HepG2 whole cell lysate
      Lane 2: A549 whole cell lysate
      Lane 3: HT29 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 63 kDa
      Observed band size: 63 kDa
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA022640LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA022640LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品描述：

    The production of the SPTLC2 antibody starts by immunizing rabbits with the recombinant human SPTLC2 (88-562aa), follows by collecting the rabbit serum, and finishes by isolating and purifying the antibody from the rabbit serum through protein G affinity chromatography.

    The resulting antibody got a high purity of up to 95%. It is only reactive with human SPTLC2 protein. This rabbit anti-human SPTLC2 polyclonal antibody has passed through quality verification in multiple applications, including ELISA, WB, IHC, and IF.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SPTLC2 Polyclonal antibody
  • Uniprot No.：
    O15270
  • 基因名：
    SPTLC2
  • 别名：
    KIAA0526 antibody; LCB 2 antibody; LCB2 antibody; LCB2a antibody; Long chain base biosynthesis protein 2 antibody; Long chain base biosynthesis protein 2a antibody; Serine palmitoyl CoA transferase 2 antibody; Serine palmitoyltransferase 2 antibody; Serine palmitoyltransferase long chain base subunit 2 antibody; Serine palmitoyltransferase subunit II antibody; Serine-palmitoyl-CoA transferase 2 antibody; SPT 2 antibody; SPT2 antibody; SPTC2_HUMAN antibody; SPTLC 2 antibody; Sptlc2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Serine palmitoyltransferase 2 protein (88-562AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SPTLC2 Antibody (CSB-PA022640LA01HU)，的标记方式是Non-conjugated。对于SPTLC2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA022640LB01HU SPTLC2 Antibody, HRP conjugated ELISA
    FITC CSB-PA022640LC01HU SPTLC2 Antibody, FITC conjugated
    Biotin CSB-PA022640LD01HU SPTLC2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

引用文献

产品评价

靶点详情

  • 功能：
    Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate. Plays an important role in de novo sphyngolipid biosynthesis which is crucial for adipogenesis.
  • 基因功能参考文献：
    1. 2 families had late-onset autosomal dominant HSAN1C caused by a new variant in SPTLC2, c.547C>T, p.(Arg183Trp). The variant changed a conserved amino acid. PMID: 26573920
    2. The activities of the hLCB2a mutants were measured in the presence of ssSPTa and ssSPTb and was found that all decrease enzyme activity. PMID: 24175284
    3. Mutations in SPTLC2 are associated with increased deoxySL formation causing hereditary sensory and autonomic neuropathy type 1 (HSANI) in a familial study. PMID: 23658386
    4. Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I. PMID: 20920666
    5. results suggest that SPTLC2 mutations are not a common cause for genetic sensory neuropathies. PMID: 12207934
    6. an increase in transepidermal water loss is an obligatory trigger for the upregulation of serine palmitoyltransferase mRNA expression in human epidermis PMID: 12445191
    7. Results suggest that functional serine palmitoyltransferase is not a dimer, but a higher organized complex, composed of three distinct subunits (SPTLC1, SPTLC2 and SPTLC3) with a molecular mass of 480 kDa. PMID: 17331073
    8. discovery of 2 proteins, ssSPTa and ssSPTb, which each interacts with both hLCB1 and hLCB2, suggesting that there are 4 distinct human SPT isozymes. PMID: 19416851

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  • 相关疾病：
    Neuropathy, hereditary sensory and autonomic, 1C (HSAN1C)
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    Class-II pyridoxal-phosphate-dependent aminotransferase family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 11278

    OMIM: 605713

    KEGG: hsa:9517

    STRING: 9606.ENSP00000216484

    UniGene: Hs.435661