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SQRDL Antibody

  • 货号：
    CSB-PA022646GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y6N5
  • 基因名：
    SQOR
  • 别名：
    0610039J17Rik antibody; 4930557M22Rik antibody; CGI 44 antibody; CGI44 antibody; mitochondrial antibody; PRO1975 antibody; SQRD_HUMAN antibody; Sqrdl antibody; Sulfide dehydrogenase like antibody; Sulfide quinone reductase like antibody; Sulfide quinone reductase-like (yeast) antibody; Sulfide:quinone oxidoreductase antibody; Sulfide:quinone oxidoreductase, mitochondrial antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SQRDL
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). It is believed the in vivo electron acceptor is glutathione.
  • 基因功能参考文献：
    1. The evidence supported the significant role of SQRDL in the etiology of postmenopausal osteoporosis and suggest that it may be a genetic risk factor for BMD and osteoporosis in Han Chinese postmenopausal women. PMID: 29855663
    2. Hydrogen Sulfide Oxidation Catalyzed by Human Sulfide Quinone Oxidoreductase PMID: 26318450
    3. Therefore, this study reveals the reduction in SQR activity as one of the pathomechanisms associated with Coenzyme Q deficiency syndrome. PMID: 27856619
    4. Data, including data from studies using recombinant SQR immobilized by embedding in nanodiscs, suggest that immobilized SQR exhibits enhanced catalytic performance; pre-steady-state kinetic characterization of immobilized SQR catalytic cycle indicates that glutathione serves as physiologically relevant sulfur acceptor during hydrogen sulfide oxidation. PMID: 28512131
    5. The I264T SQRDL polymorphism is associaated with osteoporosis in Korean postmenopausal women. PMID: 26258864
    6. SQR is part of the human mitochondrial hydrogen sulfide oxidation pathway PMID: 25225291
    7. Sulfide:quinone oxidoreductase catalyzes the first step in hydrogen sulfide metabolism and produces a sulfane sulfur metabolite. PMID: 22852582

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  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    SQRD family
  • 数据库链接：

    HGNC: 20390

    OMIM: 617658

    KEGG: hsa:58472

    STRING: 9606.ENSP00000260324

    UniGene: Hs.511251