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  4. SREBF2 Antibody

SREBF2 Antibody

  • 中文名称：
    SREBF2兔多克隆抗体
  • 货号：
    CSB-PA549727
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA549727(SREBF2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA549727(SREBF2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q12772
  • 基因名：
    SREBF2
  • 别名：
    SREBF2; BHLHD2; SREBP2; Sterol regulatory element-binding protein 2; SREBP-2; Class D basic helix-loop-helix protein 2; bHLHd2; Sterol regulatory element-binding transcription factor 2
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human SREBF2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane. Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis.; Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Regulates transcription of genes related to cholesterol synthesis pathway.
  • 基因功能参考文献：
    1. SREBF2 polymorphism rs2269657 showed significant dual associations with LOAD pathological biomarkers and gene expression levels. Furthermore, SREBF2 expression levels measured in LOAD frontal cortices inversely correlated with age at death; suggesting a possible influence on survival rate. PMID: 29503034
    2. SREBP-2 regulates autophagy-related gene expression in human liver cells. PMID: 29336468
    3. High SREBP-2 expression is associated with hypercholesterolemia. PMID: 29678744
    4. By altering the membrane trafficking through the lysosomes, cholesterol redistributes and regulates SREBP-2. PMID: 28696297
    5. The gene polymorphism of SREBP2 not only significantly associated with the clinical phenotypes of osteonecrosis of the femoral head but also closely related to lipid metabolism disorder. PMID: 28901487
    6. The current investigation indicated that the rs2267439C/T polymorphism in the SREBF-2 gene increased the T2D susceptibility in an Iranian population. PMID: 29601949
    7. Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis. PMID: 28676202
    8. CpG sites located in SREBF2 gene showed differential methylation in association with total cholesterol. The expression of the SREBF2 was inversely associated with methylation of its corresponding CpGs. PMID: 28173150
    9. Acidic pH-responsive SREBP2 target genes were associated with reduced overall survival of cancer patients. PMID: 28249167
    10. these clinical and experimental results reveal a novel role of SREBP-2 in the induction of a stem cell-like phenotype and prostate cancer metastasis PMID: 26883200
    11. These results seem to suggest an involvement of SREBF-2 in the integrity of white matter tracts in bipolar disorder and therefore a possible role of SREBP pathway in CNS myelination processes. PMID: 27771555
    12. High expression of SREBF2 is associated with high carotid intima-media thickness. PMID: 27841945
    13. mechanistic investigation provides clinical insights into protective roles of the epithelial cholesterol deficiency against excessive inflammatory responses via the SREBP2-HuR circuit, although the deficiency triggers transient pro-inflammatory signals. PMID: 27703009
    14. Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells. PMID: 27778136
    15. Identify a novel signaling pathway in hepatocytes triggered by ligand-activated p75NTR that via p38 MAPK and caspase-3 mediate the activation of SREBP2. This pathway may regulate LDLRs and lipid uptake particularly after injury or during tissue inflammation accompanied by an increased production of growth factors, including NGF and pro-NGF. PMID: 26984409
    16. The connections of EGFR and ERBB4 signaling with SREBP-2-regulated cholesterol metabolism are likely to be important in ERBB-regulated developmental processes and may contribute to metabolic remodeling in ERBB-driven cancers. PMID: 26535009
    17. knockdown of endogenous SREBP2 in HepG2 cells lowered ACSL1 mRNA and protein levels. PMID: 26728456
    18. Data suggest lysophosphatidylcholine (LPC) up-regulates SREBP-2 and cholesterol efflux in vascular endothelium; 25-hydroxycholesterol (25-HC) inhibits these effects of LPC; both LPC and 25-HC up-regulate release of interleukin-6 and interleukin-8. PMID: 25998247
    19. the results of the present study showed that luteolin modulates HMGCR transcription by decreasing the expression and nuclear translocation of SREBP-2. PMID: 26302339
    20. HCV core protein disturbs the cholesterol homeostasis in HepG2 cells via the SREBP2 pathway; miR-185-5p is involved in the regulation of SREBP2 by the core protein. PMID: 25914460
    21. the 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR)-induced activation of AMPK directly inhibited the expression of SREBP-2 and HMGCR and HMGCS, and suppressed the TSH-stimulated up-regulation of SREBP-2 in HepG2 cells. PMID: 25933205
    22. Suggest important role for SREBP-2 in regulation of lipid and glucose metabolism in hypertensive rats. PMID: 24908080
    23. Our results show that though leptin stimulates LDLR expression very weakly through JAK-STAT signaling pathway, it mainly imposes inhibition on LDLR expression by inhibiting transcription factor SREBP2 PMID: 25488447
    24. The results of this study suggested that the genetic polymorphisms of SREBF2 gene may be associated with metabolic syndrome in patients treated with clozapine. PMID: 25201120
    25. SREBP-2 rs2228314 G to C change and variant C genotype as well as LXRalpha rs11039155 G to A change and variant A may contribute to PCOS in Chinese Han population PMID: 25005769
    26. The SREBP-induced NOD-like receptor family pyrin domain-containing protein inflammasome and its instigation of innate immunity is an important contributor to atherosclerosis. PMID: 25188917
    27. The results of this study provide evidence that the GG genotype and G carrier (CG+GG) of rs2228314 G>C polymorphism in the SREBP-2 gene may increase the risk of NAFLD. PMID: 24992162
    28. findings suggest that SREBP2-miR-92a-inflammasome exacerbates endothelial dysfunction during oxidative stress PMID: 25550450
    29. SREBP-2 rs2228314 G to C change and variant C genotype may contribute to knee osteoarthritis risk in a Chinese Han population. PMID: 24496149
    30. Data show that forkhead transcription factor 4 (FoxO4) interacts with sterol regulatory element binding protein (SREBP)2 and hypoxia inducible factor (HIF)2alpha to modulate lanosterol 14alpha demethylase (CYP51) promoter activity. PMID: 24353279
    31. Rating SREBF2 polymorphism did not reveal a relationship to the occurrence of ischemic heart disease in patients with obstructive sleep apnea, both in the whole group as well as separate subgroups. PMID: 24868893
    32. A single nucleotide polymorphism that tags both the XRCC6 and SREBF2 genes strongly modifies the association between bladder cancer risk and smoking PMID: 24382701
    33. SREBP cleavage regulates Golgi-to-endoplasmic reticulum recycling of SREBP cleavage-activating protein (SCAP) PMID: 24478315
    34. These results suggest that SREBP-2 negatively regulates the FXR-mediated transcriptional activation of the FGF19 gene in human intestinal cells. PMID: 24321096
    35. Results suggested that interaction of SREBP-2 gene polymorphisms and the relationship between the polymorphisms and clinical phenotype of IGFBP-3 were closely related to increased ANFH risk in the Chinese population. PMID: 23158139
    36. Atheroprone flow induces NLRP3 inflammasome in endothelium through SREBP2 activation. PMID: 23838163
    37. Data indicate that SREBP-2 and Scap are regulated by factors driving prostate growth, and suggest exploring this observation further could shed light on prostate carcinogenesis. PMID: 23454642
    38. Starvation regulates endothelial lipase expression via SREBP-2. PMID: 23102786
    39. RNAi-mediated inhibition of SREBP2 expression significantly ameliorated the cholesterol accumulation induced by inflammatory cytokines in HepG2 cells. PMID: 23044239
    40. Results demonstrated, for the first time, the association of SREBP-2 with osteoarthritis pathogenesis and provided evidence on the molecular mechanism involved. PMID: 22662110
    41. Endoplasmic reticulum stress-induced SREBP-2 activation contributes to renal proximal tubule cell injury by dysregulating lipid homeostasis. PMID: 22573382
    42. SREBP-2 is directly linked as a target of amyloid-beta protein in cholesterol homeostasis impairment. PMID: 22573671
    43. SREBP-2 1784 G/C polymorphism is associated with non-alcoholic fatty liver disease in Asian Indians in north India. PMID: 22182810
    44. Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms. PMID: 21944868
    45. A combination oral contraceptive maintained a high-profile expression of LDLR through the stimulation of its transcription factor SREBP2 in primary placental trophoblasts and Jar cell line. PMID: 21757058
    46. could not identify any association between SREBF-2 1784G > C or SCAP 2386A > G SNPs and premature coronary artery disease or extent of coronary lesions in a Chinese population. PMID: 20111910
    47. results demonstrate for the first time that HIV-1 transcription in T cells is linked to cholesterol homeostasis through control of TFII-I expression by SREBP2 PMID: 21613400
    48. hepatic NPC1L1 in the liver from Chinese female gallstone patients may be mediated by SREBP2 PMID: 20144195
    49. miR-33 expression from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation PMID: 20732877
    50. Data show that miR-33 is encoded within SREBP-2 and that both mRNAs are coexpressed. PMID: 20566875

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  • 亚细胞定位：
    [Sterol regulatory element-binding protein 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.; [Processed sterol regulatory element-binding protein 2]: Nucleus.
  • 蛋白家族：
    SREBP family
  • 组织特异性：
    Ubiquitously expressed in adult and fetal tissues.
  • 数据库链接：

    HGNC: 11290

    OMIM: 600481

    KEGG: hsa:6721

    STRING: 9606.ENSP00000354476

    UniGene: Hs.443258