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SRGAP3 Antibody

  • 货号：
    CSB-PA102253
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA102253(SRGAP3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    O43295
  • 基因名：
    SRGAP3
  • 别名：
    ARHGAP 14 antibody; ARHGAP14 antibody; Gbi antibody; ME GAP antibody; MEGAP antibody; Mental disorder associated GAP antibody; Mental disorder-associated GAP antibody; Rho GTPase activating protein 14 antibody; Rho GTPase-activating protein 14 antibody; SLIT ROBO Rho GTPase activating protein 3 antibody; SLIT-ROBO Rho GTPase-activating protein 3 antibody; srGAP 2 antibody; srGAP 3 antibody; srGAP2 antibody; srGAP3 antibody; SRGP 2 antibody; SRGP2 antibody; SRGP3_HUMAN antibody; WAVE associated Rac GTPase activating protein antibody; WAVE-associated Rac GTPase-activating protein antibody; WRP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human SRGAP3
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.
  • 基因功能参考文献：
    1. A single PXXP motif in the C-terminal region of srGAP3 mediates binding to multiple SH3 domains. PMID: 25819436
    2. Nuclear-localized srGAP3 interacts with Brg1. This interaction is mediated by the C-terminal of srGAP3 and the ATPase motif of Brg1. PMID: 24561795
    3. deletion of SRGAP3 provides the most convincing explanation for our patient's phenotype, and our observations lend further weight to a causative role of SRGAP3 haploinsufficiency in mental retardation. PMID: 24300292
    4. conclude that srGAP3 has tumor suppressor-like activity in HMECs, likely through its activity as a negative regulator of Rac1 PMID: 23108406
    5. putative role in severe mental retardation PMID: 12195014
    6. Data suggest that MEGAP negatively regulates cell migration by perturbing the actin and microtubule cytoskeleton and by hindering the formation of focal complexes. PMID: 16730001
    7. We found no association between SRGAP3/MEGAP haploinsufficiency and mental retardation. PMID: 19433673
    8. Current evidence suggests that SRGAP3 is the major determinant of mental retardation in distal 3p deletions. PMID: 19760623
    9. FNBP2, ARHGAP13, ARHGAP14 and ARHGAP4 constitute the FNBP2 family characterized by FCH, RhoGAP and SH3 domains. PMID: 12736724

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  • 相关疾病：
    A chromosomal aberration involving SRGAP3 is found in a patient with severe idiopathic mental retardation (PubMed:12195014). Translocation t(X;3)(p11.2;p25) (PubMed:12195014).
  • 组织特异性：
    Highly expressed in adult and fetal brain. Expressed at low levels in kidney. Isoform 3 is expressed in the kidney but is absent in the brain.
  • 数据库链接：

    HGNC: 19744

    OMIM: 606525

    KEGG: hsa:9901

    STRING: 9606.ENSP00000373347

    UniGene: Hs.654743