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SRPX Antibody

  • 货号：
    CSB-PA022689LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: U87 whole cell lysate
      All lanes: SRPX antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 52, 50, 46, 42 kDa
      Observed band size: 52 kDa
    • IHC image of CSB-PA022689LA01HU diluted at 1:600 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SRPX Polyclonal antibody
  • Uniprot No.：
    P78539
  • 基因名：
    SRPX
  • 别名：
    SRPX antibody; ETX1 antibody; Sushi repeat-containing protein SRPX antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Sushi repeat-containing protein SRPX protein (31-237AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SRPX Antibody (CSB-PA022689LA01HU)，的标记方式是Non-conjugated。对于SRPX Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA022689LB01HU SRPX Antibody, HRP conjugated ELISA
    FITC CSB-PA022689LC01HU SRPX Antibody, FITC conjugated
    Biotin CSB-PA022689LD01HU SRPX Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction.
  • 基因功能参考文献：
    1. SRPX1 co-accumulated with Abeta deposits in cerebral blood vessels of all autopsied cases with severe cerebral amyloid angiopathy (CAA); no SRPX1 co-accumulated with Abeta deposits in senile plaques. Furthermore, we demonstrated that both Abeta40 and Abeta42 bound to SRPX1 in vitro and enhanced SRPX1 expression in primary cultures of cerebrovascular smooth muscle cells. SRPX1 enhanced caspase activity induced by Abeta40. PMID: 28478503
    2. The SRPX protein contains the P-DUDES structural domain in its C-terminal region. This domain has significant albeit remote sequence similarity to thioredoxin-like domains, and is predicted to possess an oxidoreductase function. PMID: 209648
    3. PELO is subcellularly localized at the actin cytoskeleton, interacts with HAX1, EIF3G and SRPX proteins and that this interaction occurs at the cytoskeleton; this interaction may facilitate PELO to detect and degrade aberrant mRNAs. PMID: 20406461
    4. An apoptosis-inducing protein localized in the endoplasmic reticulum which increases efficiency of apoptosis PMID: 15021917
    5. expression of drs mRNA in well-differentiated, moderately differentiated, and poorly differentiated lung adenocarcinoma tissues (drs; down-regulated by v-scr) PMID: 12152160
    6. down-regulation of drs mRNA is closely correlated with carcinomas which arise from adenomatous polyps in the course of the adenoma-carcinoma sequence, but most carcinomas arising de novo are independent of the tumor suppressor function of the drs gene PMID: 12716466
    7. Down-regulation of drs mRNA is closely correlated with development of prostate carcinoma, suggesting a tumor-suppressor function of the drs gene in this cancer. PMID: 12874760
    8. Downregulation of drs tumor suppressor gene in highly malignant human pulmonary neuroendocrine tumors. PMID: 19424611
    9. This is the first report demonstrating overexpression of ETX1 in glaucomatous trabecular meshwork. PMID: 19862339

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  • 亚细胞定位：
    Cell surface. Note=Possibly surface of photoreceptor cell.
  • 组织特异性：
    Retina and heart; less in placenta, pancreas, lung, liver, skeletal muscle, kidney and brain.
  • 数据库链接：

    HGNC: 11309

    OMIM: 300187

    KEGG: hsa:8406

    STRING: 9606.ENSP00000367794

    UniGene: Hs.15154