SRRM4 Antibody
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) SRRM4 Polyclonal antibody
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Uniprot No.:A7MD48
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基因名:SRRM4
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别名:SRRM4 antibody; KIAA1853 antibody; Serine/arginine repetitive matrix protein 4 antibody; Medulloblastoma antigen MU-MB-2.76 antibody; Neural-specific serine/arginine repetitive splicing factor of 100 kDa antibody; Neural-specific SR-related protein of 100 kDa antibody; nSR100 antibody
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宿主:Rabbit
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反应种属:Human, Mouse, Rat
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免疫原:Recombinant Human Serine/arginine repetitive matrix protein 4 protein (400-479AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
本页面中的产品,SRRM4 Antibody (CSB-PA012292LA01HU),的标记方式是Non-conjugated。对于SRRM4 Antibody,我们还提供其他标记。见下表:
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:>95%, Protein G purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
产品提供形式:Liquid
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应用范围:ELISA, WB, IHC
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推荐稀释比:
Application Recommended Dilution WB 1:500-1:5000 IHC 1:500-1:1000 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts. Promotes alternative splicing of REST transcripts to produce REST isoform 3 (REST4) with greatly reduced repressi...显示更多
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基因功能参考文献:
- data indicate that SRRM4 regulates alternative RNA splicing of the Bif-1 gene that enables PCa cells resistant to apoptotic stimuli under anti-cancer therapies, and may contribute to AdPC progression into t-NEPC. PMID: 29759485
- SRRM4 regulates alternative splicing programs to drive neuroendocrine prostate cancer progression (an aggressive subtype of castration-resistant prostate cancer) under androgen receptor pathway inhibition. PMID: 27180064
- Neuronal activity-dependent microexons are nSR100 targets and are misregulated in autism. PMID: 27984743
- The splicing of REST by SRRM4 could promote the neuroendocrine phenotype in CRPC. PMID: 26071481
- Neural microexons are regulated by the neuronal-specific splicing factor nSR100/SRRM4, through its binding to adjacent intronic enhancer motifs; neural microexons are frequently misregulated in the brains of individuals with autism spectrum disorder, and this misregulation is associated with reduced levels of nSR100. PMID: 25525873
- findings show that nSR100 plays a role in the alternative splicing of REST in small cell lung cancer (SCLC); study provides new insight into the role of nSR100 in the expression of sREST, possibly in the pathogenesis of SCLC PMID: 23928058
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亚细胞定位:Nucleus.
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蛋白家族:NSR100 family
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组织特异性:Specifically expressed in neuronal cells (at protein level). Expressed in the cerebellum.
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数据库链接:
HGNC: 29389
OMIM: 613103
KEGG: hsa:84530
STRING: 9606.ENSP00000267260
UniGene: Hs.744964