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SRSF10 Antibody

  • 货号：
    CSB-PA525638LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA525638LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SRSF10 Polyclonal antibody
  • Uniprot No.：
    O75494
  • 基因名：
    SRSF10
  • 别名：
    40 kDa SR repressor protein antibody; 40 kDa SR-repressor protein antibody; Anti TLS associated protein with SR repeats antibody; arginine/serine-rich 13A antibody; FUS interacting protein serine arginine rich 1 antibody; FUS interacting protein serine arginine rich 2 antibody; FUS interacting serine arginine rich protein 1 antibody; FUS-interacting serine-arginine-rich protein 1 antibody; FUSIP1 antibody; FUSIP2 antibody; NSSR antibody; OTTHUMP00000015774 antibody; Serine arginine repressor protein 40 kDa antibody; Serine/arginine-rich splicing factor 10 antibody; SFRS13 antibody; SFRS13A antibody; Splicing factor antibody; Splicing factor arginine serine rich 13 antibody; Splicing factor SRp38 antibody; SRp38 antibody; SRp40 antibody; SRrp40 antibody; SRS10_HUMAN antibody; Srsf10 antibody; TASR antibody; TASR1 antibody; TASR2 antibody; TLS associated protein TASR1 antibody; TLS associated protein TASR2 antibody; TLS associated protein with Ser Arg repeats antibody; TLS associated protein with SR repeats antibody; TLS associated serine arginine protein 1 antibody; TLS associated serine arginine protein 2 antibody; TLS associated serine arginine protein antibody; TLS associated SR protein antibody; TLS-associated protein with Ser-Arg repeats antibody; TLS-associated protein with SR repeats antibody; TLS-associated serine-arginine protein antibody; TLS-associated SR protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Serine/arginine-rich splicing factor 10 protein (1-183AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SRSF10 Antibody (CSB-PA525638LA01HU)，的标记方式是Non-conjugated。对于SRSF10 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA525638LB01HU SRSF10 Antibody, HRP conjugated ELISA
    FITC CSB-PA525638LC01HU SRSF10 Antibody, FITC conjugated
    Biotin CSB-PA525638LD01HU SRSF10 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator.
  • 基因功能参考文献：
    1. DNA damage co-opts SRSF10 to control splicing decisions in transcripts encoding components involved in DNA repair, cell-cycle control, and apoptosis. PMID: 27851963
    2. Results show that YTHDC1 promotes exon inclusion in targeted mRNAs through recruiting pre-mRNA splicing factor SRSF3 while blocking SRSF10 mRNA binding. PMID: 26876937
    3. SRSF10 is a key regulator of BCLAF1 pre-mRNA splicing and the maintenance of oncogenic features in human colon cancer cells PMID: 25091051
    4. In colorectal cancer, NSSR1 was highly expressed in the nucleus of tumor cells. PMID: 21984158
    5. Splicing thermotolerance is acquired through maintenance of SRSF10 phosphorylation and that this is mediated at least in part by Hsp27. PMID: 21135127
    6. Data show that SFRS13A expression was significantly associated with LDLR splicing efficiency in vivo. PMID: 20232416
    7. found to be dephosphorylated specifically in mitotic cells; show that dephosphorylated SRp38 is required for the observed splicing repression PMID: 12419250
    8. SRp38 plays a crucial role in cell survival under stress conditions by inhibiting the splicing machinery PMID: 14765198
    9. SRp38 contains two arginine- and serine-rich domains (RS), one of which has a unique, second-step repression activity, while both function together as a splicing repression domain. PMID: 16135820

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  • 亚细胞定位：
    Nucleus speckle. Cytoplasm.
  • 蛋白家族：
    Splicing factor SR family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 16713

    OMIM: 605221

    KEGG: hsa:10772

    STRING: 9606.ENSP00000420195

    UniGene: Hs.3530