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SRSF4 Antibody

  • 货号：
    CSB-PA021156ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: SRSF4 antibody at 4µg/ml + Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 57 kDa
      Observed band size: 57 kDa
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA021156ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA021156ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品描述：

    The polyclonal antibody against SRSF4 was synthesized in rabbits that were immunized with the recombinant human SRSF4 (1-180aa). The antibody was subsequently isolated and underwent antigen affinity purification. It shows exclusive reactivity with human SRSF4 protein.

    The SRSF4 antibody has been validated for use in ELISA, WB, and IHC applications. This antibody can thus be used for localization and qualitative or quantitative evaluation of the SRSF4 protein. SRSF4 protein mainly helps to promote efficient splicing of the pre-mRNA into the correct mRNA isoform. It is also implicated in other cellular processes, such as mRNA export from the nucleus to the cytoplasm, translation initiation, and mRNA stability.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SRSF4 Polyclonal antibody
  • Uniprot No.：
    Q08170
  • 基因名：
    SRSF4
  • 别名：
    arginine/serine-rich 4 antibody; Pre mRNA splicing factor SRP75 antibody; Pre-mRNA-splicing factor SRP75 antibody; Serine/arginine-rich splicing factor 4 antibody; Splicing factor antibody; Splicing factor, arginine/serine rich 4 antibody; Splicing factor, arginine/serine rich, 75-KD antibody; SRP001LB antibody; SRP75 antibody; Srsf4 antibody; SRSF4_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Serine/arginine-rich splicing factor 4 protein (1-180AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.
  • 基因功能参考文献：
    1. Review of the role of serine and arginine rich splicing factor 4 (SRSF4) in physiology, gene expression regulation and disease. PMID: 29789787
    2. Many of the splicing alterations induced by cisplatin are caused by SRSF4 and they contribute to apoptosis in a process requires class I PI3K. PMID: 25884497
    3. SRp75 inhibits splicing of tau exon 10 by binding to the CA repeat in the intronic splicing silencer downstream of the exon, and requires hnRNPG to exert its full regulatory effect on tau exon 10. PMID: 21723381
    4. Serine- and arginine-rich proteins 55 and 75 (SRp55 and SRp75) induce production of HIV-1 vpr mRNA by inhibiting the 5'-splice site of exon 3. PMID: 20685659
    5. the c.1002-1110_1113delTAAG mutation creates a new intronic splicing regulatory element in intron 6b of the CFTR gene exclusively recognized by SRp75 PMID: 19759008

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  • 亚细胞定位：
    Nucleus speckle.
  • 蛋白家族：
    Splicing factor SR family
  • 数据库链接：

    HGNC: 10786

    OMIM: 601940

    KEGG: hsa:6429

    STRING: 9606.ENSP00000362900

    UniGene: Hs.469970