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SRSF5 Antibody

  • 货号：
    CSB-PA050022
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q13243
  • 基因名：
    SRSF5
  • 别名：
    arginine/serine-rich 5 antibody; Delayed early protein HRS antibody; Delayed-early protein HRS antibody; HRS antibody; Pre mRNA splicing factor SRP40 antibody; Pre-mRNA-splicing factor SRP40 antibody; Serine and arginine rich splicing factor 5 antibody; Serine/arginine-rich splicing factor 5 antibody; SFRS 5 antibody; SFRS5 antibody; Splicing factor antibody; Splicing factor arginine/serine rich 5 antibody; SRP 40 antibody; SRP40 antibody; SRSF5 antibody; SRSF5_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human SRp40.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
  • 基因功能参考文献：
    1. Study found that SRSF5 is a novel target of SRSF3. SRSF5 is overexpressed in oral squamous cell carcinoma (OSCC) and functions as an oncogene. Its downregulation in OSCC cell lines slows cell growth, cycle progression, and tumor growth. The expression of SRSF5 seems to controlled by an autoregulation mechanism. PMID: 29857020
    2. upon glucose intake, the splicing factor SRSF5 is specifically induced through Tip60-mediated acetylation on K125, which antagonizes Smurf1-mediated ubiquitylation. SRSF5 promotes the alternative splicing of CCAR1 to produce CCAR1S proteins, which promote tumor growth by enhancing glucose consumption and acetyl-CoA production. PMID: 29942010
    3. we show that ErbB3 interacts with the ESCRT-0 subunit Hrs both in the presence and absence of heregulin. This indicates an ESCRT-mediated sorting of ErbB3 to late endosomes and lysosomes, and in line with this we show that impaired ESCRT function leads to an endosomal accumulation of ErbB3. PMID: 28867611
    4. the up-regulated expression of SRSF 5-7 proteins in LC with much more profound up-regulation in SCLC than in NSCLC and suggest that up-regulation of the SRSFs is related to SCLC proliferation. Moreover, we identified SRSF5 as a novel detection marker for SCLC and pleural metastatic cancer cells. PMID: 27565915
    5. this study demonstrates that HRS acts as a key component of TLR7 signaling to orchestrate immune and inflammatory responses during EV71 infection PMID: 28854257
    6. Enhanced SRSF5 Protein Expression Reinforces Lamin A mRNA Production in HeLa Cells and Fibroblasts of Progeria Patients PMID: 26670336
    7. Suggest that SRp40 might be associated with GRalpha transcripts in systemic lupus erythematosus patients. PMID: 25665148
    8. We show that changes in alternative splicing of hnRNP A/B, affected by up regulation of SRSF5 (SRp40) or by treatment with C6-ceramide, occur within supraspliceosomes. PMID: 22100336
    9. Here, the s report that specific SR proteins, particularly SRp40 and SRp55, promote human immunodeficiency virus type 1 (HIV-1) Gag translation from unspliced (intron-containing) viral RNA. PMID: 20427542
    10. SRp40 antagonizes ASF/SF2 and SRp55 by competing for binding to certain sites in exon 5, thereby promoting TF exon 5 exclusion, an event unique to asTF biosynthesis. PMID: 19843576
    11. SRp40 regulates the switch in splicing from production of CREMtau(2)alpha to CREMalpha PMID: 16103121

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Splicing factor SR family
  • 数据库链接：

    HGNC: 10787

    OMIM: 600914

    KEGG: hsa:6430

    STRING: 9606.ENSP00000377892

    UniGene: Hs.632326