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SSU72 Antibody

  • 货号：
    CSB-PA865091LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of PC-3 cells with CSB-PA865091LA01HU at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SSU72 Polyclonal antibody
  • Uniprot No.：
    Q9NP77
  • 基因名：
    SSU72
  • 别名：
    CTD phosphatase SSU72 antibody; HSPC182 antibody; Hypothetical protein FLJ10947 antibody; PNAS-120 antibody; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 antibody; ssu72 antibody; Ssu72 RNA polymerase II CTD phosphatase homolog antibody; Ssu72 RNA polymerase II CTD phosphatase homolog (yeast) antibody; SSU72_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human RNA polymerase II subunit A C-terminal domain phosphatase SSU72 protein (1-194AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SSU72 Antibody (CSB-PA865091LA01HU)，的标记方式是Non-conjugated。对于SSU72 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA865091LB01HU SSU72 Antibody, HRP conjugated ELISA
    FITC CSB-PA865091LC01HU SSU72 Antibody, FITC conjugated
    Biotin CSB-PA865091LD01HU SSU72 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.
  • 基因功能参考文献：
    1. a hand-off model in which Ssu72 mediates a conformational transition in TFIIB, accounting for the role of Ssu72 in transcription reinitiation, gene looping, and promoter-terminator cross-talk. PMID: 29158257
    2. Aurora B kinase directly targets Ssu72 phosphatase for regulation of sister chromatid cohesion during early mitosis. PMID: 24149858
    3. The pSer7 phosphatase activity of Ssu72 is approximately 4000-fold lower than its pSer5 phosphatase activity toward a peptide substrate PMID: 23070812
    4. Data suggest that Ssu72 is a novel cohesin-binding protein capable of regulating cohesion between sister chromatid arms. PMID: 20818333
    5. crystal structure at 2.4 A resolution of the amino-terminal domain (residues 30-340) of human symplekin in a ternary complex with the Pol II carboxy-terminal domain (CTD) Ser 5 phosphatase Ssu72 and a CTD Ser 5 phosphopeptide PMID: 20861839
    6. Molecular cloning and characterization of functions of human ssu72. PMID: 15659578

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=Predominantly in the cytosol.
  • 蛋白家族：
    SSU72 phosphatase family
  • 数据库链接：

    HGNC: 25016

    OMIM: 617680

    KEGG: hsa:29101

    STRING: 9606.ENSP00000291386

    UniGene: Hs.30026