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SSX2 Antibody

  • 货号：
    CSB-PA778235
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA778235(SSX2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q16385
  • 基因名：
    SSX2
  • 别名：
    Cancer/testis antigen 5.2 antibody; Cancer/testis antigen family 5, member 2a antibody; Cancer/testis antigen family 5, member 2b antibody; CT5.2 antibody; CT5.2A antibody; CT5.2b antibody; HD21 antibody; hom mel 40 antibody; HOM-MEL-40 antibody; MGC119055 antibody; MGC15364 antibody; MGC3884 antibody; Protein SSX2 antibody; RP11-552J9.2 antibody; sarcoma, synovial, X-chromosome related 2 antibody; SSx antibody; SSX2 antibody; SSX2-SYT fusion gene, included antibody; SSX2_HUMAN antibody; SSX2B antibody; Synovial sarcoma antibody; synovial sarcoma X breakpoint 2 antibody; Synovial sarcoma, X breakpoint 2B antibody; Tumor antigen HOM-MEL-40 antibody; X breakpoint 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human SSX2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Could act as a modulator of transcription.
  • 基因功能参考文献：
    1. We conclude from these findings that SSX2 expression in prostate cancer is not a driver of the epithelial to mesenchymal transition (EMT), but is involved in processes associated with EMT including loss of focal adhesion that may be related to tumor cell dissemination PMID: 27276714
    2. results reveal two important phenotypes of ectopic SSX2 expression that may drive/support tumorigenesis: First, immediate induction of genomic instability, and second, long-term support of tumor cell growth. PMID: 25363656
    3. The tumor-specific pattern of expression of SSX2. PMID: 24681846
    4. primary autoantibodies against intracellular MM-specific tumor antigens SSX-2 and NY-ESO-1 are rare but functional in multiple myeloma patients after allogeneic stem cell transplantation PMID: 25078248
    5. SSX2, SSX3, and SSX4 are expressed in the lung tissue of only 3.5% early-stage non-small cell lung cancer patients. PMID: 24645645
    6. the initial events that likely occur when SYT-SSX2 is first expressed, and its dominant function in subverting the nuclear program of the stem cell, leading to its aberrant differentiation, as a first step toward transformation PMID: 21996728
    7. The regulation of estrogen receptor alpha signaling by target proteins of SSX2 may explain the metastatic potential of breast cancer cells. PMID: 22344619
    8. The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RABIN3, and a novel nuclear protein, SSX2IP. PMID: 12007189
    9. We report the identification of an HLA-DR3-restricted epitope mapping to the 37-51 region of SSX-2. PMID: 15596411
    10. RT-PCR detection of SSX2 in paraffin-embedded tissue allowed for molecular diagnosis of synovial sarcoma. PMID: 15735574
    11. Two kinds of cancer-testis antigen, SSX-2 and SSX-5 showed high-specific and high-frequent expression in hepatocellular carcinoma tissues, but neither of them could be detected in adjacent non-HCC tissues. PMID: 16546222

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  • 相关疾病：
    A chromosomal aberration involving SSX2 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    SSX family
  • 组织特异性：
    Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and
  • 数据库链接：

    HGNC: 11336

    OMIM: 300192

    KEGG: hsa:6757

    STRING: 9606.ENSP00000364665

    UniGene: Hs.289105