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ST6GALNAC3 Antibody

  • 货号：
    CSB-PA836724LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ST6GALNAC3 Polyclonal antibody
  • Uniprot No.：
    Q8NDV1
  • 基因名：
    ST6GALNAC3
  • 别名：
    ST6GALNAC3 antibody; SIAT7C antibody; UNQ2787/PRO7177Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 antibody; EC 2.4.99.7 antibody; GalNAc alpha-2,6-sialyltransferase III antibody; ST6GalNAc III antibody; ST6GalNAcIII antibody; STY antibody; Sialyltransferase 7C antibody; SIAT7-C antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 protein (40-305AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ST6GALNAC3 Antibody (CSB-PA836724LA01HU)，的标记方式是Non-conjugated。对于ST6GALNAC3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA836724LB01HU ST6GALNAC3 Antibody, HRP conjugated ELISA
    FITC CSB-PA836724LC01HU ST6GALNAC3 Antibody, FITC conjugated
    Biotin CSB-PA836724LD01HU ST6GALNAC3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis. Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity.
  • 基因功能参考文献：
    1. genome-wide association study in population in Finland: Data suggest that one SNP in ST6GALNAC3 (rs12144344) and two SNPs in VDBP (vitamin D binding protein; rs7041, rs705117) are associated with serum levels of VDBP in the male population studied. PMID: 24740207
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    3. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20421487
    4. Results describe the molecular cloning and expression of human ST6GalNAc III, including its tissue distribution and substrate specificity. PMID: 16169874
    5. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18519826

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  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 29 family
  • 组织特异性：
    Expressed in brain and kidney. Observed in the epithelium of the proximal tubules, marginal expression was also found in the distal tubules and collecting tubules.
  • 数据库链接：

    HGNC: 19343

    OMIM: 610133

    KEGG: hsa:256435

    STRING: 9606.ENSP00000329214

    UniGene: Hs.337040