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ST6GALNAC6 Antibody

  • 货号：
    CSB-PA850251LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA850251LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) ST6GALNAC6 Polyclonal antibody
  • Uniprot No.：
    Q969X2
  • 基因名：
    ST6GALNAC6
  • 别名：
    ST6GALNAC6 antibody; SIAT7F antibody; UNQ708/PRO1359 antibody; Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 antibody; EC 2.4.99.- antibody; GalNAc alpha-2,6-sialyltransferase VI antibody; ST6GalNAc VI antibody; ST6GalNAcVI antibody; hST6GalNAc VI antibody; Sialyltransferase 7F antibody; SIAT7-F antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 protein (65-333AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，ST6GALNAC6 Antibody (CSB-PA850251LA01HU)，的标记方式是Non-conjugated。对于ST6GALNAC6 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA850251LB01HU ST6GALNAC6 Antibody, HRP conjugated ELISA
    FITC CSB-PA850251LC01HU ST6GALNAC6 Antibody, FITC conjugated
    Biotin CSB-PA850251LD01HU ST6GALNAC6 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen. Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside).
  • 基因功能参考文献：
    1. novel substrate specificity of ST6GalNAc VI, which is responsible for the synthesis of disialyl Lea but not for alpha-series gangliosides in human colon tissues PMID: 12668675
    2. ST6GalNAc-VI and disialylgalactosylgloboside were found in proximal tubule epithelial cells in normal kidney tissues PMID: 17123352
  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 29 family
  • 组织特异性：
    Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines.
  • 数据库链接：

    HGNC: 23364

    OMIM: 610135

    KEGG: hsa:30815

    STRING: 9606.ENSP00000291839

    UniGene: Hs.109672