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STAU1 Antibody

  • 货号：
    CSB-PA13759A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse lung tissue, Human placenta tissue
      All lanes: STAU1 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 64, 55, 56 kDa
      Observed band size: 64 kDa
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA13759A0Rb at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA13759A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) STAU1 Polyclonal antibody
  • Uniprot No.：
    O95793
  • 基因名：
    STAU1
  • 别名：
    Double stranded RNA binding protein Staufen homolog 1 antibody; Double stranded RNA binding protein Staufen homolog antibody; Double-stranded RNA-binding protein Staufen homolog 1 antibody; FLJ25010 antibody; MGC124588 antibody; PPP1R150 antibody; STAU antibody; STAU1 antibody; STAU1_HUMAN antibody; staufen antibody; Staufen RNA binding protein (Drosophila) antibody; Staufen RNA binding protein homolog 1 antibody; Staufen, Drosophila, homolog of, 1 antibody; Staufen, RNA binding protein, homolog 1 (Drosophila) antibody; staufen-like antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Double-stranded RNA-binding protein Staufen homolog 1 protein (163-403AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，STAU1 Antibody (CSB-PA13759A0Rb)，的标记方式是Non-conjugated。对于STAU1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA13759B0Rb STAU1 Antibody, HRP conjugated ELISA
    FITC CSB-PA13759C0Rb STAU1 Antibody, FITC conjugated
    Biotin CSB-PA13759D0Rb STAU1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.; (Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process.
  • 基因功能参考文献：
    1. recruited to mutant ATXN2 aggregates in spinocerebellar ataxia type 2 fibroblasts PMID: 30194296
    2. Staufen1 has differential roles in embryonal versus alveolar rhabdomyosarcoma through the control of proliferative and apoptotic pathways, respectively. PMID: 28211476
    3. Mechanistically, we suggest that SNHG5 stabilizes the target transcripts by blocking their degradation by STAU1. Accordingly, depletion of STAU1 rescues the apoptosis induced after SNHG5 knockdown. Hence, we characterize SNHG5 as a lncRNA promoting tumour cell survival in colorectal cancer. PMID: 28004750
    4. E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1/CDKN2B signaling axis. PMID: 28569791
    5. ADAR1p110 isoform competitively inhibits binding of Staufen1 to the 3'-untranslated-region dsRNAs and antagonizes Staufen1-mediated mRNA decay. PMID: 28436945
    6. Stau1 is a stress response gene that remains efficiently translated during hypoxia and ER stress despite the substantial global inhibition of cap-dependent protein translation, promoting cell recovery following stress PMID: 27644878
    7. Our findings suggest that HCV may appropriate Stau1 to its advantage to prevent PKR-mediated inhibition of eIF2alpha, which is required for the synthesis of HCV proteins for translocation of viral RNA genome to the polysomes for efficient translation and replication. PMID: 27106056
    8. together, these data highlight the broad impact of Stau1 as a splicing regulator and suggest that Stau1 may act as a disease modifier in DM1. PMID: 26824521
    9. expression of human Staufen1 is essential for proper dendritic arborisation during neuroblastoma cell differentiation, yet it is not necessary for maintenance of differentiated state, and suggest potential human Stauf1 mRNA targets involved in the process PMID: 25423178
    10. The changing pattern of STAU distribution during meiotic maturation of human oocytes implicates a novel mechanism for the regulation of protein synthesis based on mRNA localization PMID: 25620022
    11. in vivo atlas of mRNA secondary structures recognized by Staufen 1 PMID: 25799984
    12. TINCR, together with Staufen1, seems to stabilize a subset of mRNAs required for epidermal differentiation. PMID: 24019000
    13. A common sequence signature consisting of two opposite-polarity Alu motifs was present in the hStau1-associated mRNAs and was shown to be sufficient for binding to hStau1 and hStau1-dependent stimulation of protein expression. PMID: 24470147
    14. Staufen1 is an important factor in HCV replication and it might play a role early in the HCV replication cycle, rather than virion morphogenesis. PMID: 23907398
    15. STAU1 binding to a 3'-UTR SBS was previously shown to trigger STAU1-mediated mRNA decay (SMD) by directly recruiting the ATP-dependent RNA helicase UPF1 PMID: 24056942
    16. These results suggest a new role for Staufen-1 as a cellular Rec and human endogenous retrovirus family HERV-K Gag cofactor. PMID: 23926355
    17. this study reports the identification of two new hGIP-interacting partners, DTX1 and STAU1. PMID: 23395680
    18. The regulation of STAU1 mediated mRNA decay efficiency by NS1 may contribute to building a more favorable cellular environment for viral replication. PMID: 23722113
    19. STAU1 binding to 3' UTR IRAlus functions along with 3' UTR IRAlus-mediated nuclear retention to suppress the shutdown of cellular translation triggered by PKR binding to endogenous cytoplasmic dsRNAs PMID: 23824540
    20. SSM-mediated hSTAU1 dimerization increases the efficiency of SMD by augmenting hSTAU1 binding to the ATP-dependent RNA helicase hUPF1 PMID: 23524536
    21. TDP-43 is physically associated with fragile X mental retardation protein (FMRP) and Staufen (STAU1) to form a functional complex. PMID: 22584570
    22. For Stau1-mediated mRNA decay, Stau1 binds to the 3' untranslated region of target mRNA and recruits Upf1 to elicit rapid mRNA degradation. PMID: 22503102
    23. our results unravel a novel function for Staufen1 in splicing regulation and indicate that it may positively modulate the complex DM1 phenotype PMID: 22431750
    24. the specific region responsible for the interaction between Stau1 and influenza A Virus NS1 was identified. PMID: 21945618
    25. findings that the binding of STAU1 to mRNAs can be transactivated by long non-coding RNAs uncovers an unexpected strategy that cells use to recruit proteins to mRNAs and mediate the decay of these mRNAs PMID: 21307942
    26. Gag specifically recruited Staufen1 to the detergent insoluble membranes supporting a key function for this host factor during virus assembly. PMID: 20459747
    27. These results indicate a role for hStau1 in late events of the influenza virus infection, possibly during virus morphogenesis. PMID: 20504931
    28. Work provides new evidence that Staufen1-containing HIV-1 RNPs preferentially form over other cellular silencing foci and are involved in assembly, localization and encapsidation of vRNA. PMID: 20053637
    29. The oligomeric composition of Stau1-containing complexes and the presence of specific mRNAs have been confirmed by biochemical approaches involving two successive immunoprecipitations of Stau1-tagged molecules followed by qRT-PCR amplification. PMID: 20075165
    30. Data show that the Staufen isoform Stau(55)co-fractionates with ribosomes, suggesting that it plays some role in translation. PMID: 12133005
    31. These data show that Staufen, pr55(Gag), and genomic RNA are part of the same intracellular complex and support a role for Staufen in pr55(Gag) function in viral assembly, genomic RNA encapsidation, and the generation of infectious viral particles. PMID: 15024055
    32. The identity of proteins present in staufen complexes from RNA granules indicates that staufen has a role in transport and translation of messenger RNAs. PMID: 15121898
    33. Stau1 influences HIV-1 assembly by modulating pr55Gag-pr55Gag interactions, as shown in a live cell interaction assay PMID: 17428849
    34. Stau1 influences the expression of a wide variety of physiologic transcripts and metabolic pathways. PMID: 17510634
    35. Stau1- and Stau2-mRNPs associate with distinct but overlapping sets of cellular mRNAs. PMID: 18094122
    36. 12 amino acids at the N-terminal end of Stau1 is necessary to increase Pr55Gag multimerization and particle release. PMID: 18498651
    37. isolated a novel transcript of STAU1, coding a novel isoform that has six amino acids more (SFPLKQ) than isoform a PMID: 18806890

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  • 亚细胞定位：
    Cytoplasm. Rough endoplasmic reticulum. Note=Localizes exclusively with the rough reticulum endoplasmic (RER).
  • 组织特异性：
    Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta.
  • 数据库链接：

    HGNC: 11370

    OMIM: 601716

    KEGG: hsa:6780

    STRING: 9606.ENSP00000360922

    UniGene: Hs.596704