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STAU2 Antibody

  • 货号：
    CSB-PA885729ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA885729ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) STAU2 Polyclonal antibody
  • Uniprot No.：
    Q9NUL3
  • 基因名：
    STAU2
  • 别名：
    39K2 antibody; 39K3 antibody; DKFZp781K0371 antibody; Double stranded RNA binding protein Staufen homolog 2 antibody; Double-stranded RNA-binding protein Staufen homolog 2 antibody; MGC119606 antibody; STAU 2 antibody; stau2 antibody; STAU2_HUMAN antibody; Staufen (Drosophila; RNA-binding protein) homolog 2 antibody; Staufen double-stranded RNA binding protein 2 antibody; Staufen homolog 2 antibody; Staufen RNA binding protein homolog 2 antibody; Staufen; RNA binding protein; homolog 2 (Drosophila) antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Double-stranded RNA-binding protein Staufen homolog 2 protein (1-100AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body.
  • 基因功能参考文献：
    1. during genotoxic stress, Stau2 is downregulated at the promoter level in an ATR- and E2F1-dependent manner, leading to increased levels of DNA damage and apoptosis. PMID: 26843428
    2. s establish that human Staufen-2, a host factor which is up-regulated upon HIV-1 infection, interacts with HIV-1 Rev, thereby promoting its RNA export activity and progeny virus formation. PMID: 24520823
    3. Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity. PMID: 23263869
    4. We suggest a role for Stau2 in the generation and regulation of Map1b mRNA containing granules that are required for mGluR-long-term depression PMID: 21508097
    5. Data show that Stau2 is localized to the neuronal soma and dendrites, but it does not colocalize with Stau1-containing particles. PMID: 12140260
    6. Stau1- and Stau2-mRNPs associate with distinct but overlapping sets of cellular mRNAs. PMID: 18094122

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Nucleus, nucleolus. Endoplasmic reticulum.
  • 数据库链接：

    HGNC: 11371

    OMIM: 605920

    KEGG: hsa:27067

    STRING: 9606.ENSP00000428756

    UniGene: Hs.561815