STEAP2 Antibody
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货号:CSB-PA275156
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规格:¥2024
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图片:
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其他:
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) STEAP2 Polyclonal antibody
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Uniprot No.:Q8NFT2
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基因名:STEAP2
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别名:STEAP2; PCANAP1; STAMP1; UNQ6507/PRO23203; Metalloreductase STEAP2; Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; PUMPCn; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1
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宿主:Rabbit
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反应种属:Human,Mouse
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免疫原:Synthesized peptide derived from C-terminal of Human STEA2.
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免疫原种属:Homo sapiens (Human)
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克隆类型:Polyclonal
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纯化方式:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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浓度:It differs from different batches. Please contact us to confirm it.
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产品提供形式:Liquid
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应用范围:ELISA,IHC,IF
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推荐稀释比:
Application Recommended Dilution IHC 1:50-1:100 IF 1:100-1:500 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.
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基因功能参考文献:
- Over-expression of STEAP2 is associated with prostate cancer progression. PMID: 25248617
- Data suggest that STAMP1 is required for prostate cancer growth. PMID: 20587517
- Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
- cloning and characterization of STAMP1, which is expressed in both normal prostate and prostate neoplasms PMID: 12095985
- STEAP2 is involved in the development of prostate cancer. As a cell-surface antigen, it is a potential diagnostic or therapeutic target in prostate cancer. PMID: 12429817
- Expression of STAMP2, a gene highly similar to STAMP1 (STEAP2), in prostate cancer cells significantly increases cell growth and colony formation suggesting that STAMP2 may have a role in cell proliferation. PMID: 15897894
- STEAPs may represent novel markers of mesenchymal stem cells in man as well as mice. PMID: 19196137
- The murine ortholog, Steap2, is a ferrireductase, cupric reductase, and stimulates cellular uptake of both iron and copper in vitro. PMID: 16609065
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亚细胞定位:Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
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蛋白家族:STEAP family
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组织特异性:Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.
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数据库链接:
HGNC: 17885
OMIM: 605094
KEGG: hsa:261729
STRING: 9606.ENSP00000287908
UniGene: Hs.489051
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