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STEAP2 Antibody

  • 货号:
    CSB-PA275156
  • 规格:
    ¥2024
  • 图片:
    • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using STEA2 antibody.
    • Immunofluorescence analysis of A549 cells, using STEA2 antibody.
  • 其他:

产品详情

  • 产品名称:
    Rabbit anti-Homo sapiens (Human) STEAP2 Polyclonal antibody
  • Uniprot No.:
    Q8NFT2
  • 基因名:
    STEAP2
  • 别名:
    STEAP2; PCANAP1; STAMP1; UNQ6507/PRO23203; Metalloreductase STEAP2; Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; PUMPCn; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1
  • 宿主:
    Rabbit
  • 反应种属:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from C-terminal of Human STEA2.
  • 免疫原种属:
    Homo sapiens (Human)
  • 克隆类型:
    Polyclonal
  • 纯化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度:
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式:
    Liquid
  • 应用范围:
    ELISA,IHC,IF
  • 推荐稀释比:
    Application Recommended Dilution
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols:
  • 储存条件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能:
    Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.
  • 基因功能参考文献:
    1. Over-expression of STEAP2 is associated with prostate cancer progression. PMID: 25248617
    2. Data suggest that STAMP1 is required for prostate cancer growth. PMID: 20587517
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    4. cloning and characterization of STAMP1, which is expressed in both normal prostate and prostate neoplasms PMID: 12095985
    5. STEAP2 is involved in the development of prostate cancer. As a cell-surface antigen, it is a potential diagnostic or therapeutic target in prostate cancer. PMID: 12429817
    6. Expression of STAMP2, a gene highly similar to STAMP1 (STEAP2), in prostate cancer cells significantly increases cell growth and colony formation suggesting that STAMP2 may have a role in cell proliferation. PMID: 15897894
    7. STEAPs may represent novel markers of mesenchymal stem cells in man as well as mice. PMID: 19196137
    8. The murine ortholog, Steap2, is a ferrireductase, cupric reductase, and stimulates cellular uptake of both iron and copper in vitro. PMID: 16609065

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  • 亚细胞定位:
    Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    STEAP family
  • 组织特异性:
    Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.
  • 数据库链接:

    HGNC: 17885

    OMIM: 605094

    KEGG: hsa:261729

    STRING: 9606.ENSP00000287908

    UniGene: Hs.489051