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STEAP4 Antibody

  • 货号：
    CSB-PA060158
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q687X5
  • 基因名：
    STEAP4
  • 别名：
    STEAP4; STAMP2; TNFAIP9; Metalloreductase STEAP4; Six-transmembrane epithelial antigen of prostate 4; SixTransMembrane protein of prostate 2; Tumor necrosis factor, alpha-induced protein 9
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human STAMP2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate. Can also reduce Cu(2+) to Cu(1+). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses. Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation.
  • 基因功能参考文献：
    1. These findings suggest that increased STEAP4 mRNA expression is associated with inflammatory stimuli, whereas lower STEAP4 expression is associated with obesity in human islets. PMID: 28405880
    2. STEAP4 plays role in metal homeostasis is critical to the maintenance of cellular homeostasis , and in preventing the onset of metabolic disease. [review] PMID: 28576871
    3. a down regulation of STEAP4 and up-regulation of HIF-1alpha are observed in morbidly obese patients PMID: 27058639
    4. The expression of TNFAIP9 significantly decreased in the adipose tissue of obese children, and its levels are closely related to blood lipid level, insulin resistance, and obesity. PMID: 27706555
    5. the expression of STEAP4 was significantly downregulated in the adipose tissue of obese children. PMID: 27808366
    6. Some SNPs of the STEAP4 gene altered the risk of developing a metabolic syndrome in the Han Chinese population. PMID: 26510124
    7. These data suggest that STAMP2 is required for prostate cancer progression and thus may serve as a novel therapeutic target. PMID: 25680860
    8. may interact with mitochondria [review] PMID: 24643198
    9. Our results show increased mRNA expression of STEAP4 and NGAL in human visceral adipose tissue in obese patients. PMID: 23179203
    10. Our findings revealed that STAMP2 gene polymorphisms are likely to significantly contribute to the risk of MetS in male Han Chinese population. PMID: 23953178
    11. three polymorphisms (rs8122, rs1981529 and rs34741656) of STAMP2 gene may be not related with type 2 diabetes mellitus in Xinjiang Uygur population PMID: 23134829
    12. STEAP4 was highly induced in human adipose cells differentiated in the presence of 1,25D. PMID: 23553608
    13. STAMP2 antagonizes HBx-mediated hepatocyte dysfunction, thereby protecting hepatocytes from hepatitis B virus gene expression. PMID: 23095254
    14. STEAP4 genetic variations are likely to be associated with obesity-related insulin resistance in Uygur Chinese general population. PMID: 21718614
    15. STEAP4 is expressed on monocytes and neutrophils in peripheral blood of patients with rheumatoid arthritis. PMID: 22244520
    16. STEAP4 might potentially suppress the pathogenesis of TNFalpha-induced arthritis such as rheumatoid arthritis. PMID: 21633911
    17. an association of the common variation rs1981529 (Gly75Asp, 224A/G) in the STEAP4 gene with obesity in Uygur general population PMID: 21933608
    18. Decreased STAMP2 expression (mRNA and protein) might reflect visceral adipose dysfunction in subjects with obesity and type 2 diabetes. PMID: 21849520
    19. The knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via the attenuated phosphorylation of Akt, independent of the effects of EEA1. PMID: 21468601
    20. There was no association of the three polymorphisms (rs8122, rs1981529 and rs34741656) in the STAMP2 gene with essential hypertension in Xinjiang Uygur population. PMID: 21287513
    21. STEAP 4 genetic polymorphisms may be associated with metabolic syndrome risk in Chinese Uygur population. PMID: 21287516
    22. Fourteen novel and six known single nucleotide polymorphisms (SNPs) including 2 nonsynonymous SNPs in the STEAP4 gene were identified. SNPs rs8122 and rs1981529 were significantly associated with the metabolic syndrome phenotype in females. PMID: 21044749
    23. common polymorphisms of STAMP2 are unlikely to significantly contribute to the risk of the metabolic syndrome in the general population PMID: 20382686
    24. Results demonstrate that STEAP4 does not influence human adipocyte differentiation, but it participates in regulating the insulin sensitivity of human adipocytes. PMID: 20127040
    25. Human WAT STAMP2 associates with obesity and insulin resistance independently of adiponectin. PMID: 18381574
    26. Down-regulation of STEAP4 is associated with obesity in humans. PMID: 18430367
    27. TIARP/STAMP2 is highly upregulated in 3T3-L1 cells and hMSC-Ad by IL-1beta and might, therefore, modulate proinflammatory and insulin resistance-inducing effects of IL-1beta. PMID: 19289123
    28. STEAP4 associates with focal adhesion kinase (FAK) and regulate the activity of FAK through Y397 phosphorylation. PMID: 19787193

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    STEAP family
  • 组织特异性：
    Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and
  • 数据库链接：

    HGNC: 21923

    OMIM: 611098

    KEGG: hsa:79689

    STRING: 9606.ENSP00000369419

    UniGene: Hs.521008