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STH Antibody

  • 货号：
    CSB-PA022827LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA022827LA01HU diluted at 1:600 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA022827LA01HU diluted at 1:600 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) STH Polyclonal antibody
  • Uniprot No.：
    Q8IWL8
  • 基因名：
    STH
  • 别名：
    STH antibody; Saitohin antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Saitohin protein (1-128AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，STH Antibody (CSB-PA022827LA01HU)，的标记方式是Non-conjugated。对于STH Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA022827LB01HU STH Antibody, HRP conjugated ELISA
    FITC CSB-PA022827LC01HU STH Antibody, FITC conjugated
    Biotin CSB-PA022827LD01HU STH Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Saitohin Q7R polymorphism is associated with late-onset Alzheimer's disease susceptibility among caucasian populations. (Meta-analysis) PMID: 28211174
    2. Results showed a significant interaction effect of COMT and STH polymorphisms on cognitive performances, strengthening the involvement of STH in cognitive impairments, especially in the domains commonly impaired in schizophrenia PMID: 25283873
    3. The rs6203857 polymorphism of the saitohin gene is a genetic risk factor for Parkinson's disease. PMID: 25168738
    4. results of this meta-analysis suggested that MAPT_238bp/STH Q7R polymorphisms might modulate the risk of Parkinson's disease susceptibility PMID: 25305495
    5. These results suggest a possible contribution of STH gene products on the heterogeneity of core frontal executive functions deterioration in schizophrenia PMID: 22187337
    6. Single polymorphisms within the saitohin gene were associated with increased cognitive impairment and functional dependence persons with moderate-to-advanced Alzheimer disease. PMID: 21934306
    7. effect of Saitohin on Abl-mediated phosphorylation appears to be allele-specific, providing evidence for a new cellular function for STH PMID: 21769920
    8. STH polymorphisms play a possibly shared role with those of serotinin transporter 5-HTTLPR gene as a susceptibility factor for Alzheimer's disease and frontotemperal lobar dementia. PMID: 20852909
    9. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20852909
    10. a gene within an intron of the tau gene; Q7R polymorphism appears to be over-represented in the homozygous state in late onset Alzheimer's disease subjects PMID: 12032355
    11. The saitohin Q allele, a novel determinant of tau H1 haplotypes, may represent a causative factor involved in the determinism of several tauopathies, e.g., frontotemporal dementia. PMID: 12447938
    12. At the STH gene only a common polymorphic change was found. PMID: 12826737
    13. Increased risk of Alzheimer's disease associated with the STH RR genotype is limited to late-onset Alzheimer's disease. PMID: 12826738
    14. The R allele of STH is associated with the H2 haplotype of tau; no correlation is found between R allele frequency and Alzheimer's or Parkinson's disease. PMID: 12932819
    15. Saitohin interacts with peroxiredoxin 6, a unique member of that family that is bifunctional and the levels of which increase in Pick disease. PMID: 16186110
    16. We found no evidence that could support a major pathogenic role of STH and TAU haplotype in AD, FTD or PD. PMID: 16909000
    17. Q allele of STH gene is over-represented in a tested group of patients with Huntington disease and might be considered a risk factor for HD like diseases. PMID: 18300012
    18. Homozygous Q/Q of STH Q7R polymorphism was the only one genotype found in either LOAD group or controls. No R allele was detected in LOAD and control groups. PMID: 18396294
    19. The Saitohin Q7R polymorphism is unlikely to contribute significantly to Alzheimer's disease susceptibility of the Han population in south China. PMID: 18850062
    20. Observational study of gene-disease association. (HuGE Navigator) PMID: 18850062
    21. Observational study of gene-disease association. (HuGE Navigator) PMID: 18509094
    22. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 18396294
    23. Observational study of genotype prevalence. (HuGE Navigator) PMID: 18300012
    24. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 18307033
    25. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 15136700
    26. Observational study of gene-disease association. (HuGE Navigator) PMID: 16603077
    27. Observational study of gene-disease association. (HuGE Navigator) PMID: 16909000

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 组织特异性：
    Highest expression in placenta, muscle, fetal brain, and adult brain, with lower expression in heart, kidney, stomach, testis, and adrenal gland. In the central nervous system, highest expression is in temporal lobe, hypothalamus, medulla and spinal cord,
  • 数据库链接：

    HGNC: 18839

    OMIM: 607067

    KEGG: hsa:246744

    STRING: 9606.ENSP00000443168

    UniGene: Hs.661831