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  4. STK26 Antibody

STK26 Antibody

  • 中文名称：
    STK26兔多克隆抗体
  • 货号：
    CSB-PA958497
  • 规格：
    ￥1100
  • 图片：
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human fetal brain tissue, 293T cells, Hela cells, Primary antibody: CSB-PA958497(STK26 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q9P289
  • 基因名：
    STK26
  • 别名：
    2610018G03Rik antibody; EC 2.7.11.1 antibody; Mammalian Ste20 like protein kinase 4 antibody; Mammalian STE20-like protein kinase 4 antibody; Mammalian sterile 20 like 4 antibody; MASK antibody; MST 4 antibody; MST-4 antibody; MST3 and SOK1 related kinase antibody; Mst3 and SOK1-related kinase antibody; Mst4 antibody; MST4_HUMAN antibody; RGD1563568 antibody; RP23-245F8.1 antibody; RP6 213H19.1 antibody; Serine/threonine protein kinase 26 antibody; Serine/threonine protein kinase MASK antibody; Serine/threonine protein kinase MST 4 antibody; Serine/threonine protein kinase MST4 antibody; Serine/threonine-protein kinase MASK antibody; Serine/threonine-protein kinase MST4 antibody; STE20 like kinase MST 4 antibody; STE20 like kinase MST4 antibody; STE20-like kinase MST4 antibody; STK26 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human STK26
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation.
  • 基因功能参考文献：
    1. Our work describes an MST4-ATG4B signaling axis that influences glioblastoma autophagy and malignancy PMID: 29232556
    2. Low MST-4 expression is associated with Graves' disease. PMID: 28219358
    3. these data identify the MST4 kinase as a novel candidate to mediate human pituitary tumorigenesis in a hypoxic environment and position it as a potential therapeutic target. PMID: 25650755
    4. Our results suggest that MST4, STK25 and PDCD10 are upregulated in prostate cancer and may play roles in prostate tumorigenesis. MST4 may be a helpful marker for identifying prostate cancer. PMID: 25550858
    5. Findings reveal a mechanism by which TRAF6 is regulated and highlight a role for MST4 in limiting inflammatory responses. PMID: 25642822
    6. This study describes the key role of MST4 in facilitating the epithelial-mesenchymal transition process in hepatocellular carcinoma PMID: 24859810
    7. Mutation of this residue was sufficient to switch the phosphorylation site preference for multiple kinases, including the serine-specific kinase PAK4 and the threonine-specific kinase MST4. PMID: 24374310
    8. CCM3 forms a stable complex with MST4 in vivo to promote cell proliferation and migration synergistically in a manner dependent on MST4 kinase activity. PMID: 23541896
    9. In this review, the germinal center kinase III subfamily of mammalian Ste20 (sterile 20)-like group of serine/threonine protein kinases comprises Ste20-like/oxidant-stress-response kinase 1, MST3 mammalian Ste20-like kinase 3 and MST4. PMID: 23889253
    10. crystal of the CCM3-MST4 C-terminal domain complex belonged to space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = 69.10, b = 69.10, c = 117.57 A PMID: 22750858
    11. cloning of a germinal center iii kinase that induces apoptosis PMID: 11741893
    12. MST4 expression in prostate carcinoma tumor samples & cell lines correlated with tumorigenicity & AR status. Overexpression induced anchorage-independent growth & tumorigenesis.It may have a role in the signal transduction in prostate cancer progression. PMID: 12810671
    13. Results show that PDCD10 modulation of ERK signaling is mediated by MST4, and that PDCD10 may be a regulatory adaptor necessary for MST4 function, suggesting a link between cerebral cavernous malformation and the ERK-MAPK cascade via PDCD10/MST4. PMID: 17360971
    14. These data define a brush border induction pathway downstream of the Lkb1/Strad/Mo25 polarization complex, yet separate from other polarity events. PMID: 19386264

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  • 亚细胞定位：
    Cytoplasm. Golgi apparatus.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 数据库链接：

    HGNC: 18174

    OMIM: 300547

    KEGG: hsa:51765

    STRING: 9606.ENSP00000377867

    UniGene: Hs.444247