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STK38 Antibody

  • 货号：
    CSB-PA614885ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA614885ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) STK38 Polyclonal antibody
  • Uniprot No.：
    Q15208
  • 基因名：
    STK38
  • 别名：
    NDR 1 antibody; NDR antibody; Ndr Ser/Thr kinase-like protein antibody; NDR1 antibody; NDR1 protein kinase antibody; Nuclear Dbf2 related kinase 1 antibody; nuclear Dbf2-related 1 antibody; Nuclear Dbf2-related kinase 1 antibody; Nuclear Dbf2-related protein antibody; Serine/threonine protein kinase 38 antibody; Serine/threonine-protein kinase 38 antibody; STK 38 antibody; STK38 antibody; STK38_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Serine/threonine-protein kinase 38 protein (1-200AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.
  • 基因功能参考文献：
    1. Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop. PMID: 30018336
    2. Study provides evidence for an inhibitory role of SOCS2 in TNFalpha induced NF-kappa B activation, identifies NDR1 as a novel substrate of SOCS2, and demonstrates that SOCS2 and TNFalpha induced NF-kappa B signaling are linked through NDR1. PMID: 28216640
    3. Data show that STK38 supports Ras-driven transformation through promoting detachment-induced autophagy. PMID: 27283898
    4. a novel and intimate link between the protein kinase NDR1 and TGFbeta signaling PMID: 23840619
    5. Data establish STK38 as a conserved regulator of autophagy in human cells and flies. PMID: 26387716
    6. PLK1-mediated phosphorylation protects the binding of Mob1 to NDR1 and subsequent NDR1 activation PMID: 26057687
    7. STK38-mediated phosphorylation of CDC25A at Ser-76 and the subsequent degradation of CDC25A are required to promote DNA damage-induced G2/M checkpoint activation. PMID: 25936524
    8. STK38 regulates MYC protein stability and turnover in a kinase activity-dependent manner. STK38 kinase inactivation abrogates apoptosis following B-cell receptor activation, whereas its silencing significantly decreases MYC levels and increases apoptosis. PMID: 23178486
    9. cyclin D1 has a role in promoting cell cycle progression by enhancing NDR1/2 kinase activity independent of Cdk4 PMID: 23897809
    10. 17-allylamino-17-demethoxygeldanamycin down-regulates STK38, modulating radiosensitivity. PMID: 23886587
    11. Findings suggest a function of NDR1, which may regulate NF-kappaB activation by its kinase activity. PMID: 22674419
    12. GSK-3beta inhibits full activation of STK38, and STK38 activation is required to prevent cell death in response to oxidative stress PMID: 22142472
    13. Findings show a biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR signaling. PMID: 21730291
    14. These findings establish a novel MST3-NDR-p21 axis as an important regulator of G(1)/S progression of mammalian cells. PMID: 21262772
    15. Data indicate that human MOB2 is a negative regulator of human NDR kinases in biochemical and biological settings. PMID: 20624913
    16. NDR1 and NDR2 serine-threonine kinases are regulated by mob proteins PMID: 15067004
    17. an insert within the catalytic domain between subdomains VII and VIII is autoinhibitory, and the binding of human MOB1 to the N-terminal domain of NDR induces the release of this autoinhibition. PMID: 15197186
    18. The NDR1 and NDR2 kinases were incorporated into HIV-1 particles and were cleaved by the HIV-1 protease. PMID: 15582665
    19. In vivo activation of human NDR by membrane-bound hMOBs is dependent on their interaction and occurs solely at the membrane. PMID: 16135814
    20. These data indicate that NDR-driven centrosome duplication requires Cdk2 activity and that Cdk2-induced centrosome amplification is affected upon reduction of NDR activity. PMID: 17317633
    21. phosphorylation of MOB1 at Thr74 by MST2 is essential to make a complex of MOB1, MST2 and NDR1, and to fully activate NDR1 PMID: 18362890

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family
  • 组织特异性：
    Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.
  • 数据库链接：

    HGNC: 17847

    OMIM: 606964

    KEGG: hsa:11329

    STRING: 9606.ENSP00000229812

    UniGene: Hs.409578